Protective effect of shenfu preconditioning on myocardium against ischemia-reperfusion injury in rats

CHEN Yupei; et al

doi:10.13406/j.cnki.cyxb.2005.02.016

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Protective effect of shenfu preconditioning on myocardium against ischemia-reperfusion injury in rats

更新时间：2024-01-17

- Protective effect of shenfu preconditioning on myocardium against ischemia-reperfusion injury in rats
- Journal of Chongqing Medical University Issue 2, Pages: 220-223(2005)
- 作者机构：
  
  1. 重庆医科大学第二临床学院麻醉科
  2. 重庆医科大学第二临床学院病理科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.02.016
  CLC： R285
- Published：2005，
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[1]陈玉培,牟崇明,季道如,但伶,龚文婷,马英.参附注射液预干预对大鼠心肌缺血/再灌注损伤的保护作用[J].重庆医科大学学报,2005(02):220-223+288.

CHEN Yupei, et al. Protective effect of shenfu preconditioning on myocardium against ischemia-reperfusion injury in rats. [J]. Journal of Chongqing Medical University (2):220-223(2005)
[1]陈玉培,牟崇明,季道如,但伶,龚文婷,马英.参附注射液预干预对大鼠心肌缺血/再灌注损伤的保护作用[J].重庆医科大学学报,2005(02):220-223+288. DOI： 10.13406/j.cnki.cyxb.2005.02.016.

CHEN Yupei, et al. Protective effect of shenfu preconditioning on myocardium against ischemia-reperfusion injury in rats. [J]. Journal of Chongqing Medical University (2):220-223(2005) DOI： 10.13406/j.cnki.cyxb.2005.02.016.

摘要

目的:研究参附注射液（SF）对大鼠心肌的保护效应与HSP70 的关系。方法:采用整体缺血再灌注（I/R）模型

35只大鼠随机分为假手术组（C组）、I/R组2组、SF组2组

心肌缺血4 0min再灌注30min或12 0min检测血流动力学参数

心肌MDA含量、SOD活性、HSP70的表达及超微结构。结果:与I/R组比较:SF组的LVSP、±dp/d/max均升高而LVEDP降纸（P<0 .0 5 ） ;I/R12 0min后SF组SOD活性增加、MDA含量减少（P <0 .0 5 ）、HSP70 的表达增强（P <0 .0 5 ） ;电镜显示SF组的心肌损伤程度均轻于I/R组。结论:参附对I/R心肌的保护效应与其抗氧自由基及抗脂质过氧化反应作用和促进HSP70 的表达有关

Abstract

Objective:To study the relationship between the protective effect of shenfu parenteral solution (SF) on myocardium in rats and HSP 70 .Methods:To establish general ischemia reperfusion(I/R) model.Thirty-five healthy white rats were divided into five groups randomly:sham operation group(group C)

I/R30 group (including 2 groups)

SF group(including 2 groups).After myocardial ischemia lasting for 40min

then reperfusing for 30min or 120min.To detect hemodynamic parameter

myocardium MDA content

SOD activity

HSP 70 expression and ultrastructure were examined.Results:Compare with I/R group:LVSP and ±dp/d/max rose up

however

LVEDP decreased( P <0.05) in SF group.After mycocardial ischemia lasting for 120min

SOD activity in SF group increased

MDA content decreased( P <0.05) and HSP 70 expression reinforced( P <0.05).Electron microscope showed myocardium injury was lighter in SF group than in I/R group.Conclusion:The SF protective effect on myocardium was connected with its anti-oxygen-derived free radicals and anti-lipid peroxiaation response

as well as with acceleration of HSP 70 expression.

关键词

参附注射液心肌再灌注损伤血流动力学热休克蛋白

Keywords

ShenfuMyocardial ischemia/reperfusion injuryhemodynamicsheat shock protein

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