Effects of tetrandrine on fibroblast’s proliferation derived from hypertrophic scar

CAO Zhidong; et al

doi:10.13406/j.cnki.cyxb.2005.02.011

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Effects of tetrandrine on fibroblast’s proliferation derived from hypertrophic scar

更新时间：2024-01-17

- Effects of tetrandrine on fibroblast’s proliferation derived from hypertrophic scar
- Journal of Chongqing Medical University Issue 2, Pages: 203-205(2005)
- 作者机构：
  
  1. 重庆市急救医疗中心骨科
  2. 重庆医科大学临床学院烧伤整形外科
  3. 重庆市急救医疗中心骨科,重庆,400014
  4. ,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.02.011
  CLC： R285
- Published：2005，
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[1]曹治东,石崇荣,黄崇本,陈维庭,李邦春.汉防己甲素对增生性瘢痕成纤维细胞增殖的影响[J].重庆医科大学学报,2005(02):203-205.

CAO Zhidong, et al. Effects of tetrandrine on fibroblast’s proliferation derived from hypertrophic scar. [J]. Journal of Chongqing Medical University (2):203-205(2005)
[1]曹治东,石崇荣,黄崇本,陈维庭,李邦春.汉防己甲素对增生性瘢痕成纤维细胞增殖的影响[J].重庆医科大学学报,2005(02):203-205. DOI： 10.13406/j.cnki.cyxb.2005.02.011.

CAO Zhidong, et al. Effects of tetrandrine on fibroblast’s proliferation derived from hypertrophic scar. [J]. Journal of Chongqing Medical University (2):203-205(2005) DOI： 10.13406/j.cnki.cyxb.2005.02.011.

摘要

目的:探讨汉防己甲素对增生性瘢痕成纤维细胞增殖活力的影响及其在瘢痕治疗中的意义。方法:利用瘢痕成纤维细胞体外培养模型

采用MTT记数、流式细胞仪记数及氯胺T法

观察并分析了汉防己甲素对瘢痕成纤维细胞增殖活力以及细胞外胶原量的影响

并采用直线相关法分析两者的关系。结果:汉防己甲素剂量及时间依赖性地使细胞生长曲线压低

群体倍增时间延长

细胞外胶原蛋白量减少且两者呈直线正相关。结论:汉防己甲素对增生性瘢痕成纤维细胞具有抑制作用

且此正为其抗瘢痕作用机理之一。

Abstract

Objective:To probe into the effects of tetrandrine on fibroblast proliferation derived from hypertrophic scars and evaluate the role of tetrandrine in the treatment of scars.Methods:Taking the cultured fibroblasts derived from human hypertrophic scars as model

the effects of tetrandrine on fibroblast proliferation and content of extracellular collagen were observed and analyzed by MTT reduction assay

flow cytometry after propidium iodide staining and modified chloraseptine T oxidizing assay.Besides

their relationship was analyzed by linear correlation.Results:Growth curve descent

TD prolonging and extracellular collagen reduction in a dosage and time dependent manner were observed.Moreover

they changed in positive correlation with each other.Conclusion:Tetrandrine can inhibit fibroblast biological action derived from hypertrophic scars

which is one of the mechanism of anti-scarring action of tetrandrine.

关键词

粉防己碱/药理学瘢痕增生性/药物疗法成纤维细胞

Keywords

Tetrandrine/pharmacologyScarHypertrophic/drug therapyfibroblast

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