Changed DBH expression of the neurons in lumbar sympathetic ganglia in response to Buerger’s disease of lower limb

HONG Yun; et al

doi:10.13406/j.cnki.cyxb.2005.01.042

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Changed DBH expression of the neurons in lumbar sympathetic ganglia in response to Buerger’s disease of lower limb

更新时间：2024-01-17

- Changed DBH expression of the neurons in lumbar sympathetic ganglia in response to Buerger’s disease of lower limb
- Journal of Chongqing Medical University Issue 1, Pages: 138-140(2005)
- 作者机构：
  
  1. 重庆医科大学临床学院血管外科
  2. 重庆医科大学临床学院血管外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.01.042
  CLC： R654.4
- Published：2005，
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[1]洪云,赵渝,李德卫.下肢Buerger’s病患者腰交感神经节神经元中DBH的改变[J].重庆医科大学学报,2005(01):138-140.

HONG Yun, et al. Changed DBH expression of the neurons in lumbar sympathetic ganglia in response to Buerger’s disease of lower limb. [J]. Journal of Chongqing Medical University (1):138-140(2005)
[1]洪云,赵渝,李德卫.下肢Buerger’s病患者腰交感神经节神经元中DBH的改变[J].重庆医科大学学报,2005(01):138-140. DOI： 10.13406/j.cnki.cyxb.2005.01.042.

HONG Yun, et al. Changed DBH expression of the neurons in lumbar sympathetic ganglia in response to Buerger’s disease of lower limb. [J]. Journal of Chongqing Medical University (1):138-140(2005) DOI： 10.13406/j.cnki.cyxb.2005.01.042.

摘要

目的研究下肢Buerger’s病患者腰交感神经节神经元中去甲肾上腺素合成酶——多巴胺-β-羟化酶（dopaminebetahydroxylase

DBH）的表达。方法采用免疫组织化学SP法检测14例Buerger’s病患者和11例非Buerger’s病患者腰交感神经节神经元中DBH的表达水平。结果Buerger’s病患者神经元内DBH表达有高于正常人的总体趋势

差异具有统计学意义（P<0.05）。结论DBH的表达增强可使血管更多的处于痉挛状态

促进了本病的发生发展。

Abstract

Objective:To observe the expression of dopamme beta hydroxylase (DBH) in the lumbar sympathetic ganglia neurons of the patients with Buerger’s disease of lower limb.Methods:The DBH expression of the neurons in lumbar sympathetic ganglia of 14 patients with Buerger’s disease were observed by immunohistochemistry staining.11 patients without it served as the controls.Results:The DBH expression of the patients were reinforced that of control group.Conclusion:The enhanced expression of DBH may result in vasospasm

accelerating the development of Buerger’s disease.

关键词

Buerger’s病腰交感神经节多巴胺-β-羟化酶

Keywords

Buerger’s diseaseLumbar sympathetic gangliaDopamine beta hydroxylase

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