Association between TGF-β<sub>1</sub> in allograft and chronic allograft nephropathy

WANG Pingxian; et al

doi:10.13406/j.cnki.cyxb.2005.01.015

您当前的位置：

首页 >

文章列表页 >

Association between TGF-β₁ in allograft and chronic allograft nephropathy

更新时间：2024-01-17

- Association between TGF-β₁ in allograft and chronic allograft nephropathy
- Journal of Chongqing Medical University Issue 1, Pages: 53-56(2005)
- 作者机构：
  
  1. 第三军医大学附属新桥医院泌尿外科
  2. 第三军医大学附属新桥医院泌尿外科,重庆,400037
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.01.015
  CLC： R699.2
- Published：2005，
扫描看全文
[1]王平贤,龚桂芝,徐华英,黄赤兵,范明齐,张艮甫.移植肾转化因子β与慢性移植肾肾病关系的研究[J].重庆医科大学学报,2005(01):53-56.

WANG Pingxian, et al. Association between TGF-β₁ in allograft and chronic allograft nephropathy. [J]. Journal of Chongqing Medical University (1):53-56(2005)
[1]王平贤,龚桂芝,徐华英,黄赤兵,范明齐,张艮甫.移植肾转化因子β与慢性移植肾肾病关系的研究[J].重庆医科大学学报,2005(01):53-56. DOI： 10.13406/j.cnki.cyxb.2005.01.015.

WANG Pingxian, et al. Association between TGF-β₁ in allograft and chronic allograft nephropathy. [J]. Journal of Chongqing Medical University (1):53-56(2005) DOI： 10.13406/j.cnki.cyxb.2005.01.015.

摘要

目的探讨移植肾转化生长因子β1（TGF-β1）与慢性移植肾肾病的关系。方法2000年9月～2001年6月期间

对181例肾功能正常的肾移植患者检测尿TGF-β1含量

所得相对浓度为150.7～527.1（pg/mg.Cr）

分别选出浓度最高和最低的各25例患者构成A组、B组。检测两组血TGF-β1浓度;两组中分别有16例和13例患者进行了移植肾穿刺活检

检测活检组织中TGF-β1mRNA的表达量;3年后

比较两组肾功能有无差异;分析TGF-β1mRNA表达量与肾功能有无相关性;对肾功能不全者作移植肾穿刺活检

明明是否为慢性移植肾肾病;结果两组患者血TGF-β1浓度没有明显差异;A组活检组织中TGF-β1mRNA表达量为1.37±0.29

明显高于B组（0.87±0.24）;2年后

A组肌酐清除率（Ccr）减少了17.4±6.6ml/min和2例);TGF-β1mRNA表达量与3年后的肾功能之间有着明显的相关性;肾功不全的患者

移植肾穿刺活检均证实为慢性移植肾肾病。结论TGF-β1与慢性移植物肾病的发生有着密切的关联;肾移植后检测尿TGF-β1对远期肾功能具有预测作用。

Abstract

Objective:To determine the relation between transforming growth factor β 1 （TGF-β 1）in allograft and chronic allograft nephropathy （CAN）.Methods:Urine TGF-β 1 relative concentration（divided by urine creatinine） was tested in 181 recipients whose renal function were normal between August 1

2000 and June 31

2001.25 cases with higher urine TGF-β 1 relative concentrations were assigned to group A

other 25 cases with lower urine TGF-β 1 to group B.In both groups biopsies were carried out in 16 cases and 13 cases respectively.TGF-β 1 mRNA in the biopsis was tested by RT-PCR.Blood TGF-β 1 concentrations in the two groups were also tested.Three years later

the renal function was compared between the two groups.The correlation between expression of TGF-β 1mRNA and long-term renal function was determined.Biopsies were carried out in renal recipients whose creatinine was higher than normal.Results:Blood TGF-β 1 concentrations in the two groups were not significantly different

3 years after transplantation

there was more loss of renal function and larger number of chronic allograft nephropathy （CAN） cases in group A than group B.Expression of TGF-β 1mRNA in the allografts was found more in group A than in group B.The difference in the two groups was significant.There was a correlation between expression of TGF-β 1mRNA and long-term renal function.Conclusion:The findings suggest expression of TGF-β 1mRNA in the allografts is associated with chronic allograft nephropathy.The level of urine TGF-β

after renal transplantation can predict long-term renal function.

关键词

移植肾肾病转化生长因子β1

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

FETAL SPLEEN AS A DONOR FOR TRANSPLANTAl ION

EXPERIMENTAL STUDY OF PITUITARY TRANS PLANTATION IN HYPOTHALAMUS OF RABBITS

THE STUUDY ON EXOXRINE FUNCTION OF FETALPA NCREAS──II

The effect of heme oxygenase-1 on erythropoietin protection ischemia reperfusion injury in the mouse kidney

Related Author

Yao Zhenxiang

et al.

吴凯南

涂天喜

吴诚义

缪西

霍钢

吕孟达

Related Institution

Department of General Surgery, The First Hospital

重庆医科大学中心实验室

重庆医科大学第一医院神经外科

重庆医科大学神经疾病研究室

重庆医科大学第一医院神经外科重庆医科大学神经疾病研究室

⁰

Association between TGF-β1 in allograft and chronic allograft nephropathy

DOI：10.13406/j.cnki.cyxb.2005.01.015

摘要

Abstract

关键词

Keywords

references

Association between TGF-β₁ in allograft and chronic allograft nephropathy