The effect of Astragalus injection on CCl<sub>4</sub>-ethanol-induced rat hepatic fibrosis

ZHOU Xian; et al

doi:10.13406/j.cnki.cyxb.2005.01.014

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The effect of Astragalus injection on CCl₄-ethanol-induced rat hepatic fibrosis

更新时间：2024-01-17

- The effect of Astragalus injection on CCl₄-ethanol-induced rat hepatic fibrosis
- Journal of Chongqing Medical University Issue 1, Pages: 50-52(2005)
- 作者机构：
  
  1. 重庆医科大学第二临床学院消化内科
  2. 重庆医科大学第二临床学院消化内科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.01.014
  CLC： R285
- Published：2005，
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[1]周贤,戴立里,贾丽萍,郑元义.黄芪注射液对CCl_4诱导的大鼠肝纤维化的防治[J].重庆医科大学学报,2005(01):50-52.

ZHOU Xian, et al. The effect of Astragalus injection on CCl₄-ethanol-induced rat hepatic fibrosis. [J]. Journal of Chongqing Medical University (1):50-52(2005)
[1]周贤,戴立里,贾丽萍,郑元义.黄芪注射液对CCl_4诱导的大鼠肝纤维化的防治[J].重庆医科大学学报,2005(01):50-52. DOI： 10.13406/j.cnki.cyxb.2005.01.014.

ZHOU Xian, et al. The effect of Astragalus injection on CCl₄-ethanol-induced rat hepatic fibrosis. [J]. Journal of Chongqing Medical University (1):50-52(2005) DOI： 10.13406/j.cnki.cyxb.2005.01.014.

摘要

目的探讨黄芪注射液对大鼠肝纤维化的抑制作用。方法40%CCl4和5%乙醇制备大鼠肝纤维化模型

黄芪注射液组给予黄芪注射液（800mg/kg·d）腹腔注射

模型组给予生理盐水腹腔注射;七周后测定血清透明质酸酶（HA）、层粘蛋白（LN）含量

肝组织超氧化物歧化酶（SOD）活性

丙二醛（MDA）含量

免疫组化观察肝组织LN的表达

HE、VG染色观察肝组织病理变化。结果与模型组比较

黄芪注射液组血清HA、LN明显降低（P<0.05）;肝组织MDA明显减少（P<0.01）

而SOD活性明显升高（P<0.01）;肝纤维化程度明显减轻（P<0.01）

肝组织LN表达明显减少。结论黄芪注射液可减缓肝纤维化的发生

其机制与其抗氧化作用及减少LN的产生有关。

Abstract

Objective:To investigate the inhibitive effect of Astragalus injection on CCl 4-ethanol-induced hepatic fibrosis.Methods:40% CCl 4 and 5% ethanol were used to induce hepatic fibrosis.Astragalus injection group:Astragalus injection(800mg/kg·d) was administered during formation of inducing hepatic fibrosis.Model control group only received saline.After 7 weeks

all groups were compared in terms of serum examinations(HA

LN) and liver tissue examinations(change of histology

degree of hepatic fibrosis

level of SOD and MDA

and immunohistochemistry of LN).Results:Compared with model control group

treatment of rats with Astragalus injection remarkably decreased serum HA and LN levels( P <0.05) and liver MDA level( P <0.01)

but increased the activity of liver SOD( P <0.01).Meanwhile

microscopic studies revealed that the livers of rats receiving Astragalus injection showed decrease in fibrosis formation and in expression of LN.Conclusion:Astragalus injection has inhibitive effect on experimental hepatic fibrosis formation.The mechanism is possibly associated with the action of antioxidant and the expression of decreasing LN.

关键词

肝纤维化黄芪注射液透明质酸酶层粘蛋白氧自由基

Keywords

hepatic fibrosisAstragalus injectionHALNAntioxidant

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⁰

The effect of Astragalus injection on CCl4-ethanol-induced rat hepatic fibrosis

DOI：10.13406/j.cnki.cyxb.2005.01.014

摘要

Abstract

关键词

Keywords

references

The effect of Astragalus injection on CCl₄-ethanol-induced rat hepatic fibrosis