Study of augmenter of liver regeneration in rat testis

GUO Shuquan; et al

doi:10.13406/j.cnki.cyxb.2005.01.011

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Study of augmenter of liver regeneration in rat testis

更新时间：2024-01-17

- Study of augmenter of liver regeneration in rat testis
- Journal of Chongqing Medical University Issue 1, Pages: 39-41(2005)
- 作者机构：
  
  1. 重庆医科大学第二临床学院泌尿外科
  2. 重庆医科大学病毒性肝炎研究所
  3. 重庆医科大学第二临床学院病理科
  4. 重庆医科大学第二临床学院泌尿外科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.01.011
  CLC： R691
- Published：2005，
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[1]张唯力,郭书权,刘杞,马英,乔天愚,张智.大鼠睾丸组织中ALR的研究[J].重庆医科大学学报,2005(01):39-41+45.

GUO Shuquan, et al. Study of augmenter of liver regeneration in rat testis. [J]. Journal of Chongqing Medical University (1):39-41(2005)
[1]张唯力,郭书权,刘杞,马英,乔天愚,张智.大鼠睾丸组织中ALR的研究[J].重庆医科大学学报,2005(01):39-41+45. DOI： 10.13406/j.cnki.cyxb.2005.01.011.

GUO Shuquan, et al. Study of augmenter of liver regeneration in rat testis. [J]. Journal of Chongqing Medical University (1):39-41(2005) DOI： 10.13406/j.cnki.cyxb.2005.01.011.

摘要

目的研究大鼠睾丸组织中肝再生增强因子（ALR）的表达情况

探讨睾丸ALR与生殖的关系。方法取幼年、成年、老年大鼠睾丸组织以及部分肝切除（PH）术前、术后12h、24h、48h大鼠肝脏、睾丸组织进行免疫组化

了解大鼠睾丸组织中ALR的表达。结果睾丸组织中ALR广泛存在于间质细胞、支持细胞和生精细胞

其中尤以精原细胞、精母细胞表达最强。不同年龄段ALR的表达不一样

幼年最强、成年次之、老年最弱。70%PH后肝脏ALR表达增强

24h达峰值

睾丸组织中ALR表达无明显变化。结论睾丸组织有较强ALR表达

不同脏器的ALR作用具有脏器特异性

ALR与睾丸的发育以及精子生成及成熟密切相关。

Abstract

Objective:To confirm the expression and localization of augmenter of liver regeneration(ALR) in baby

mature and the old rat testis and to evaluate the function of ALR in reproduction.Methods:ALR expression and localization in baby

mature and the old rat testis were examined by immunohistochemistry

ALR expressions of the mature rat testis and liver were examined in 12h

24h and 48h after 70 percent partial hepatectomy(PH) as well.Results:ALR was expressed in the cytoplasm and membrane of cells and it commonly existed in Leydig cells

Sertoli cells and sperm cells of rat testis

especially in spermatogonia and spermatocytes.ALR expressions differed among baby

mature and the old rat testis

in the way from the strongest to the weakest.After 70 percent PH ALR expression increased in liver

peaking in 24h

while that in testis didn’t change.Conclusion:ALR expression in testis is strong which is necessary for testis development

spermatogenesis and mature sperm.The function of ALR is organ special.

关键词

大鼠睾丸组织肝再生增强因子精子生成年龄

Keywords

ratTestisALRSpermatogenesisage

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Related Institution

Department of Urology，The First Affiliated Hospital of Chongqing Medical University

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Department of Urology,the Children’s Hospital,Chongqing Medical University,Ministry of Education Key Laboratory of Child Development and Disorders,Key Laboratory of Pediatrics in Chongqing,Chongqing International Science and Technology Cooperation Center for Child Development and Disorders

重庆医科大学第一医院临床药理研究室

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