Study on analgesic effect of rofecoxib on patients with advanced carcinoma

LUO Qiong; et al

doi:10.13406/j.cnki.cyxb.2004.06.038

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Study on analgesic effect of rofecoxib on patients with advanced carcinoma

更新时间：2024-01-17

- Study on analgesic effect of rofecoxib on patients with advanced carcinoma
- Journal of Chongqing Medical University Issue 6, Pages: 825-826(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院疗养院
  2. 重庆医科大学临床学院疗养院,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.06.038
  CLC： R730.5
- Published：2004，
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[1]罗琼,黄华.罗非昔布应用于晚期癌症止痛的疗效评价[J].重庆医科大学学报,2004(06):825-826+850.

LUO Qiong, et al. Study on analgesic effect of rofecoxib on patients with advanced carcinoma. [J]. Journal of Chongqing Medical University (6):825-826(2004)
[1]罗琼,黄华.罗非昔布应用于晚期癌症止痛的疗效评价[J].重庆医科大学学报,2004(06):825-826+850. DOI： 10.13406/j.cnki.cyxb.2004.06.038.

LUO Qiong, et al. Study on analgesic effect of rofecoxib on patients with advanced carcinoma. [J]. Journal of Chongqing Medical University (6):825-826(2004) DOI： 10.13406/j.cnki.cyxb.2004.06.038.

摘要

目的 :评价罗非昔布对晚期癌痛病人的镇痛作用。方法 :10 8例经病理学确诊的晚期癌症疼痛病人

给予口服罗非昔布片治疗

每次 2 5～ 5 0mg

每天 1次

观察病人疼痛缓解情况。结果 :罗非昔布片每天口服 1次

可以有效地控制晚期癌症病人的轻、中度疼痛

临床镇痛总有效率为 84 .2 6 %。无明显头晕

恶心

呕吐

胃部不适

便秘等不良反应。结论 :罗非昔布片对晚期癌症疼痛有明显的镇痛作用

药效持续时间长

不良反应小

使用方便。

Abstract

Objective:To study the analgesic effect of rofecoxib on patients with advanced carcinoma.Methods:In a randomized clinical trial

108 pathologically diagnosed cancer patients were treated with rofecoxib(dose 25～50mg/d) and the pain relief was observed among all the patients.Results:Rofecoxib was effective in control of cancer related pain in an oral dose of 25～50mg/day with a total effective rate of 84.26%.The main adverse reactions such as drowsiness

dizziness

nausea

vomiting

discomfort in stomach and constipation were slight.Conclusion:Rofecoxib is effective for relieving cancer related pain with sustained duration and slight in adverse reaction and convenient for administration.

关键词

罗非昔布不良反应晚期癌症止痛

Keywords

Rofecoxibadverse reactionAdvanced carcinomaAnalgesia

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Related Institution

Department of Obstetrics and Gynecology,College of Clinical Medicine,Chongqing Medical University

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