Comparison of analgesic effect on patient-controlled intravenousanalgesia among different doses of buprenorphine and tramadol

TANG Wanbi; et al

doi:10.13406/j.cnki.cyxb.2004.06.035

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Comparison of analgesic effect on patient-controlled intravenousanalgesia among different doses of buprenorphine and tramadol

更新时间：2024-01-17

- Comparison of analgesic effect on patient-controlled intravenousanalgesia among different doses of buprenorphine and tramadol
- Journal of Chongqing Medical University Issue 6, Pages: 817-819(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院麻醉科
  2. 重庆医科大学临床学院麻醉科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.06.035
  CLC： R614.2
- Published：2004，
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[1]唐万碧,张光新,唐晓宁,闵苏.丁丙诺啡和曲马多配伍用于病人静脉自控镇痛的药效比较[J].重庆医科大学学报,2004(06):817-819.

TANG Wanbi, et al. Comparison of analgesic effect on patient-controlled intravenousanalgesia among different doses of buprenorphine and tramadol. [J]. Journal of Chongqing Medical University (6):817-819(2004)
[1]唐万碧,张光新,唐晓宁,闵苏.丁丙诺啡和曲马多配伍用于病人静脉自控镇痛的药效比较[J].重庆医科大学学报,2004(06):817-819. DOI： 10.13406/j.cnki.cyxb.2004.06.035.

TANG Wanbi, et al. Comparison of analgesic effect on patient-controlled intravenousanalgesia among different doses of buprenorphine and tramadol. [J]. Journal of Chongqing Medical University (6):817-819(2004) DOI： 10.13406/j.cnki.cyxb.2004.06.035.

摘要

目的 :比较丁丙诺啡和曲马多两种长效镇痛药物联合用药不同配伍的PCIA药效及不良反应的临床观察。方法 :使用PCIA的病人 12 0例

随机分为三组

每组各 4 0例。药液配伍分别为 :Ⅰ组丁丙诺啡 0 .6mg

曲马多 4 0 0mg

氟哌利多 2 .5mg。Ⅱ组丁丙诺啡 0 .9mg

曲马多 4 0 0mg

氟哌利多 2 .5mg。Ⅲ组丁丙诺啡 0 .6mg

曲马多 6 0 0mg

氟哌利多 2 .5mg。三组病人药液中均加入生理盐水至总量为 6 0ml的复合液。PCA设置 :负荷剂量 3ml

单次剂量 1ml

连续背景输注给药 0 .0 10～ 0 .0 15ml/ （kg·h）

锁定时间 10min。观察术后 4、8、16、2 4、4 8h的BP、HR、RR、SpO2 、镇静、恶心、呕吐、眩晕、出汗、瘙痒、镇痛效果评分及药物用量。结果 :三组病人镇痛效果均满意（P >0 .0 5 ）

均无过度镇静和明显呼吸抑制

恶心、呕吐、眩晕、出汗等不良反应Ⅰ组比Ⅱ组和Ⅲ组发生率低（P >0 .0 5 ）。结论 :三组不同配伍的药液用于术后PCIA效果满意。Ⅰ组病人不良反应发生率低

是临床应用PCIA首选的最佳剂量。

Abstract

Objective:To compare the analgesic and side effects of patient-controlled intravenous analgesia (PCIA) among different doses of buprenorphine and tramadol.Methods:One hundred and twenty patients were randomly divided into three groups(Ⅰ

Ⅱ

Ⅲ

each group n =40).Patient-controlled intravenous analgesia(PCIA) was set with three solutions:In group Ⅰ the patients received PCIA with 0.6mg of buprenorphine

400mg of tramadol

2.5mg of droperidol with 0.9%N.S 47ml/60ml.In group Ⅱ the patients received PCIA with 0.9mg of buprenorphine

400mg of tramadol

2.5mg of droperidol with 0.9%N.S 45ml/60.In group Ⅲ the patients received PCIA with 0.6mg of buprenorphine

600mg of tramadol

2.5mg of droperidol with 0.9%N.S 43ml/60ml.The loading doses were 3ml

bolus dose 1ml

background infusion 0.010～0.015ml/(kg·h)

and lock-out time 10min.BP

SpO 2 and side effects (such as nausea

vomiting and dizziness)were monitored.The clinical effects were assessed by VAS score of pain and the number of PCIA pump by the patients.Results:All three solutions cauld provide better analgesia and patient satisfaction( P >0.05).All groups developed no excessive sedation and respiratory depression.Postoperative nausea

vomiting

dizziness and sweating were significantly less in group Ⅰ than in group Ⅱ and Ⅲ( P >0.05).Conclusion:Analgesic effects on PCIA with three mixtures of different doses of buprenorphine and tramadol were satisfactory.Group Ⅰ shows the lower rate of side effects and the dose is preferred in clinical use for PCIA.

关键词

病人静脉自控镇痛丁丙诺啡曲马多

Keywords

Patient-controlled intravenous analgesia (PCIA)Buprenorphinetramadol

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