Objective:To investigate the abnormity of arterioles in gallbladder and its relation with gallbladder hypomotility in patients with gallstone and diabetes mellitus.Methods:30 patients with simple gallstone and 30 patients with gallstone accompanied with diabetes mellitus were analyzed.Their gallbladder emptying function was measured with B ultrasound before operation.After operation

the arterioles of gallbladder rinsed with PAS reagent in photos were analyzed in tubular area and stereo system with BEIHANG CM-2000B biological and medical photo system.Results:The gallbladder volumes of fasting(V 0)

two hours after eating(V 2) increased (59.3±0.6 vs 37.9±5.4

44.7±6.6 vs 14.3±4.9 respectively)

whilethe ejective volume of bile(EV) and the ejective rate of gallbladder two hours after eating[GBEF 2 (%)] decreased in patients with diabetes mellitus(14.5±7.1 vs 23.4±9.3

24.9±12.7 vs 61.5±8.5

respectively).In patients with gallstone and diabetes mellitus

the area ratio of arterioles wall to whole arterioles in cross section was significantly higher than in the patients with simple gallstone(0.81 ±0.09 vs 0.58±0.15

P <0.01)

and their average sound density was also higher than the latter(0.41±0.07 vs 0.30±0.12

P <0.01).The size of arterioles(diameter) had no significant relation to the area ratio( P >0.05).Conclusion:The emptying function is significantly impaired in patients with gallstone and diabetes mellitus.The sedimentation of PAS positive material in the wall of arterioles lead to the stenosis of arterioles

and it is probably the cause for gallbladder hypomotility.