The expression and significance of hepatocytegrowth factor and c-Met receptor in endometrial carcinoma

XIAO Lin; et al

doi:10.13406/j.cnki.cyxb.2004.06.025

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The expression and significance of hepatocytegrowth factor and c-Met receptor in endometrial carcinoma

更新时间：2024-01-17

- The expression and significance of hepatocytegrowth factor and c-Met receptor in endometrial carcinoma
- Journal of Chongqing Medical University Issue 6, Pages: 789-791(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院妇产科
  2. 重庆医科大学临床学院妇产科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.06.025
  CLC： R737.33
- Published：2004，
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[1]肖琳,唐良萏.肝细胞生长因子及其受体在子宫内膜癌组织中的表达及其意义[J].重庆医科大学学报,2004(06):789-791.

XIAO Lin, et al. The expression and significance of hepatocytegrowth factor and c-Met receptor in endometrial carcinoma. [J]. Journal of Chongqing Medical University (6):789-791(2004)
[1]肖琳,唐良萏.肝细胞生长因子及其受体在子宫内膜癌组织中的表达及其意义[J].重庆医科大学学报,2004(06):789-791. DOI： 10.13406/j.cnki.cyxb.2004.06.025.

XIAO Lin, et al. The expression and significance of hepatocytegrowth factor and c-Met receptor in endometrial carcinoma. [J]. Journal of Chongqing Medical University (6):789-791(2004) DOI： 10.13406/j.cnki.cyxb.2004.06.025.

摘要

目的 :研究肝细胞生长因子HGF及其受体c-Met在子宫内膜癌组织中的表达及其与子宫内膜癌手术病理分期、病理分级的关系。方法 :采用免疫组织化学S -P法

检测 5 2例子宫内膜腺癌、12例正常子宫内膜组织中HGF及其受体c -Met的表达

并结合肿瘤的手术病理分期、病理分级

对结果进行 χ2 检验、Fisher精确概率法等统计分析

从而判断其价值。结果 :子宫内膜癌组织中HGF及c -Met表达较正常子宫内膜组织明显增高 ;子宫内膜癌的期别越晚、分化越差

c -Met表达越强。结论 :HGF、c -Met的过度表达与子宫内膜癌的发生发展有关 ;c -Met与子宫内膜癌的手术病理分期、病理分级密切相关。

Abstract

Objective:To investigate the expression and significance of hcpatocyte growth factor (HGF) and c-Met

receptor (c-Met) in endometrial carcimoma.Methods:Using S-P immunohistochemistry method

the expression of HGF and c-Met in the specimens of 52 cases with endometrial catcmoma and 16 cases with normal endometrium was examined.Then the correlation was analyzed between the two factors and the stage and differentiation of EC.Results:The expressions of HGF and c-Met in endometrial carcinoma were significantly higher than in normal endometrium.The expression of c-Met was closely associated with the stage and differentiation of endometrial carcinoma.Conclusion:Overexpression of HGF and c-Met facilitates the malignant progress of endometrium

c-Met is associated with the prognosis of EC.

关键词

子宫内膜癌肝细胞生长因子免疫组织化学

Keywords

Endometrial carcinoma (EC)Hepatocyte growth factor (HGF)immunohistochemistry

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