Effect of radiotherapy on P-glycoprotein expressionin nasopharyngeal squamous carcinoma

LIU Yu; et al

doi:10.13406/j.cnki.cyxb.2004.06.024

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Effect of radiotherapy on P-glycoprotein expressionin nasopharyngeal squamous carcinoma

更新时间：2024-01-17

- Effect of radiotherapy on P-glycoprotein expressionin nasopharyngeal squamous carcinoma
- Journal of Chongqing Medical University Issue 6, Pages: 786-788(2004)
- 作者机构：
  
  1. 重庆医科大学临床医院肿瘤科
  2. 重庆医科大学临床医院耳鼻喉科
  3. 重庆医科大学基础医学院病理教研室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.06.024
  CLC： R739.63
- Published：2004，
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[1]刘宇,张幸平,陈鸿雁,邓红彬,徐曼,李圆圆.放射治疗对鼻咽鳞癌P糖蛋白的影响[J].重庆医科大学学报,2004(06):786-788.

LIU Yu, et al. Effect of radiotherapy on P-glycoprotein expressionin nasopharyngeal squamous carcinoma. [J]. Journal of Chongqing Medical University (6):786-788(2004)
[1]刘宇,张幸平,陈鸿雁,邓红彬,徐曼,李圆圆.放射治疗对鼻咽鳞癌P糖蛋白的影响[J].重庆医科大学学报,2004(06):786-788. DOI： 10.13406/j.cnki.cyxb.2004.06.024.

LIU Yu, et al. Effect of radiotherapy on P-glycoprotein expressionin nasopharyngeal squamous carcinoma. [J]. Journal of Chongqing Medical University (6):786-788(2004) DOI： 10.13406/j.cnki.cyxb.2004.06.024.

摘要

目的 :初步探讨鼻咽鳞癌多药耐药基因（mdr - 1）产物p -糖蛋白（pgp）在放疗前、后的表达及其临床意义。方法 :应用免疫组化SP法单克隆抗体JSB - 1检测 4 8例初治的鼻咽鳞癌患者放疗前及放疗后 pgp的表达。结果 :鼻咽鳞癌组织在放疗前pgp阳性表达率为 18.75 % （9/ 4 8）

放疗后pgp阳性表达率为 75 .0 0 % （36 / 4 8）。放疗后pgp阳性率和放疗前相比有显著性差异（P <0 .0 0 1）。结论 :放射治疗明显地诱导或加强鼻咽鳞癌组织中 pgp表达

这可能是引起放、化疗交叉耐药的原因之一。

Abstract

Objective:To investigate preliminarily the expression of P-glycoprotein(pGp)

a multi-drug resistance gene-1 product

in patients with nasopharyngeal squamous carcinoma(NPSC) before and after radiotherapy.Methods:pGp was detected by immunohistochemistry with one monoclonal antibody JSB-1 before and after radiotherapy in fourty-eight patients with NPSC.None of them had received neoadjuvant chemotherapy or radiotherapy.Results:The positive rate of pGp expression in the patients with NPSC before radiotherapy was 18.75%(9/48).But the positive expression rate of pGp after radiotherapy was 75.00%(36/48).pGp expression rate after radiotherapy was significantly higher than that before radiotherapy( P <0.001).Conclusion:pGp expression in NPSC is significantly induced by radiation and radiotherapy increases the overexpression of pGp.Also radiotherapy may be one of the reasons for resistance to chemotherapy after radiotherapy.

关键词

鼻咽癌/放射治疗多药耐药性P-糖蛋白免疫组织化学

Keywords

Nasopharyngeal carcinoma/RadiotherapyMulti-drug resistanceP-glycoproteinImmunhistochemistry

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