Change of cytochrome oxidase activity in retina of monocular deprived rats

YAN Xiuju; et al

doi:10.13406/j.cnki.cyxb.2004.06.023

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Change of cytochrome oxidase activity in retina of monocular deprived rats

更新时间：2024-01-17

- Change of cytochrome oxidase activity in retina of monocular deprived rats
- Journal of Chongqing Medical University Issue 6, Pages: 784-785(2004)
- 作者机构：
  
  1. 重庆医科大学第二临床学院眼科
  2. 重庆医科大学第二临床学院眼科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.06.023
  CLC： R774.12
- Published：2004，
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[1]鄢秀菊,刘刚,周兰新.单眼视觉剥夺大鼠视网膜细胞色素氧化酶的活性变化[J].重庆医科大学学报,2004(06):784-785+794.

YAN Xiuju, et al. Change of cytochrome oxidase activity in retina of monocular deprived rats. [J]. Journal of Chongqing Medical University (6):784-785(2004)
[1]鄢秀菊,刘刚,周兰新.单眼视觉剥夺大鼠视网膜细胞色素氧化酶的活性变化[J].重庆医科大学学报,2004(06):784-785+794. DOI： 10.13406/j.cnki.cyxb.2004.06.023.

YAN Xiuju, et al. Change of cytochrome oxidase activity in retina of monocular deprived rats. [J]. Journal of Chongqing Medical University (6):784-785(2004) DOI： 10.13406/j.cnki.cyxb.2004.06.023.

摘要

目的 :研究单眼剥夺大鼠视网膜细胞色素氧化酶（CO）的活性变化。方法 :2周龄大鼠行单眼睑缘黏合

制作单眼视觉剥夺动物模型 ;DAB法观察大鼠视网膜铺片的组织化学反应情况

光学显微镜下分四个象限计数高、中、低CO活性视网膜节细胞数

间接反应视网膜细胞CO活性变化。结果 :视网膜CO阳性细胞数在剥夺眼与非剥夺眼之间存在显著差异（P <0 .0 1） ;非剥夺眼与正常对照组两眼间差异无显著性（P >0 .0 5 ）。结论 :在视觉发育敏感期内单眼剥夺

可造成大鼠剥夺眼视网膜C0阳性节细胞数下降 ;提示剥夺性弱视可能存在视网膜的异常。

Abstract

Objective:To study the changes of cytochrome oxidase (CO) activity in retina of monocular deprived rats.Methods:Deprived amblyopia rat model were established by suturing the eyelids of observed eye of 14 days old rats for one month.The retina stretched preparation were processed with CO histochemical reaction and the number of CO positive retina ganglion cells were studied under light microscope.Results:The number of CO positive retina ganglion cells decreased in deprived eyes compared with control eyes( P <0.01).Conclusion:During the developmental sensitive period of visual system

monocular depriving could induce the decrease of the number of CO positive retina ganglion cells of the deprived eye of rats.

关键词

弱视视觉剥夺细胞色素氧化酶

Keywords

AmblyopiaVisual deprivationCytochrome oxidase

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