The expression and significance of MRP and LRP in carcinoma of large intestine

LUO Wenjun; et al

doi:10.13406/j.cnki.cyxb.2004.06.018

您当前的位置：

首页 >

文章列表页 >

The expression and significance of MRP and LRP in carcinoma of large intestine

更新时间：2024-01-17

- The expression and significance of MRP and LRP in carcinoma of large intestine
- Journal of Chongqing Medical University Issue 6, Pages: 769-771(2004)
- 作者机构：
  
  1. 重庆医科大学第二临床学院普外科
  2. 重庆医科大学基础医学院病理教研室
  3. 重庆医科大学第二临床学院普外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.06.018
  CLC： R735.34
- Published：2004，
扫描看全文
[1]罗文军,易永芬,于冬青,亓荣华,唐博.大肠癌组织中肺耐药蛋白和多药耐药相关蛋白的表达及临床病理意义[J].重庆医科大学学报,2004(06):769-771.

LUO Wenjun, et al. The expression and significance of MRP and LRP in carcinoma of large intestine. [J]. Journal of Chongqing Medical University (6):769-771(2004)
[1]罗文军,易永芬,于冬青,亓荣华,唐博.大肠癌组织中肺耐药蛋白和多药耐药相关蛋白的表达及临床病理意义[J].重庆医科大学学报,2004(06):769-771. DOI： 10.13406/j.cnki.cyxb.2004.06.018.

LUO Wenjun, et al. The expression and significance of MRP and LRP in carcinoma of large intestine. [J]. Journal of Chongqing Medical University (6):769-771(2004) DOI： 10.13406/j.cnki.cyxb.2004.06.018.

摘要

目的 :检测肺耐药蛋白（LRP）和多药耐药相关蛋白（MRP）在 6 0例大肠癌组织中的表达

探讨其与组织学类型、浸润深度、淋巴结转移的关系。方法 :应用免疫组化S -P法

检测 6 0例大肠癌组织

10例正常大肠粘膜中MRP和LRP的表达情况。结果 :MRP、LRP在 6 0例大肠癌组织中的阳性表达率分别为 6 8.3%和 70 %

均高于正常大肠粘膜中阳性表达率（P <0 .0 5 ）

在各组织学类型之间的表达无明显差异（P >0 .0 5 ）

不同浸润深度及是否有淋巴结转移间表达率无差异（P >0 .0 5 ）。结论 :MRP、LRP在大肠癌中均呈高表达

在大肠癌原发性多药耐药中起重要作用

这可能是大肠癌对化疗不敏感的原因之一。

Abstract

Objective:To study the expression and clinical significance of MRP and LRP in carcinoma of large intestine.Methods:Immunohistochemistry is used to examine the MRP and LRP expression in 60 cases of large intestine carcinoma and 10 cases of normal large intestine tissues.Results:The positive expression rates of MRP and LRP in the 60 cases of large intestine carcinoma are 68.3% and 70% respectively and are all significantly higher than those in normal large intestine tissues ( P <0.05).The expression of them has no discrepancy between different depth of invasion or between lymph nodes with metastasis or without( P >0.05).Conclusion:MRP and LRP are both highly expressed in large intestine carcinoma and play an important role in the primary multidrug resistence(MDR) of large intestine carcinoma.

关键词

大肠肿瘤药物耐受性多药耐药相关蛋白肺耐药蛋白

Keywords

Large intestine neoplasmsdrug resistanceMultidrug resistance-associated proteinlung resistance protein

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

The relationship between augmenter of liver regeneration, cytochrome P450 and the drug resistance of induced human hepatocellular carcinoma drug-resistant cells in vitro

Effect of Center-Supplementing and Qi-Boosting Decoction combined siRNA on LRP expression of A549/DDP cell

Related Author

XU Yong-hong

et al

郭晖

钱克莉

张臣丽

刘杞

Li Lulu

Chi Shoujun

Related Institution

Institute for Viral Hepatitis,the Second Affiliated Hospital,Chongqing Medical University

Teaching and Research Section of Pathology，School of Basic Medicine

Teaching and Research Section of Traditional Chinese Medicine，School of Basic Medicine

Morphology Experimental Center，Major Research Platform，Liaoning University of Traditional Chinese Medicine

⁰