Expression of p57<sup>kip2</sup>   protein in bladder transitionalcell carcinoma and its significance

LI Jiabing; et al

doi:10.13406/j.cnki.cyxb.2004.06.017

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Expression of p57^kip2 protein in bladder transitionalcell carcinoma and its significance

更新时间：2024-01-17

- Expression of p57^kip2 protein in bladder transitionalcell carcinoma and its significance
- Journal of Chongqing Medical University Issue 6, Pages: 765-768(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院泌尿外科
  2. 重庆医科大学临床学院泌尿外科,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.06.017
  CLC： R737.14
- Published：2004，
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[1]李家兵,唐伟.p57~(kip2)在膀胱癌的表达及意义[J].重庆医科大学学报,2004(06):765-768.

LI Jiabing, et al. Expression of p57^kip2 protein in bladder transitionalcell carcinoma and its significance. [J]. Journal of Chongqing Medical University (6):765-768(2004)
[1]李家兵,唐伟.p57~(kip2)在膀胱癌的表达及意义[J].重庆医科大学学报,2004(06):765-768. DOI： 10.13406/j.cnki.cyxb.2004.06.017.

LI Jiabing, et al. Expression of p57^kip2 protein in bladder transitionalcell carcinoma and its significance. [J]. Journal of Chongqing Medical University (6):765-768(2004) DOI： 10.13406/j.cnki.cyxb.2004.06.017.

摘要

目的 :探讨细胞周期蛋白依赖性激酶抑制因子 p5 7kip2 蛋白在膀胱癌的表达及临床意义。方法 :采用免疫组化技术检测p5 7kip2 蛋白和增殖细胞核抗原（PCNA）在 5 0例膀胱癌和 14例正常膀胱黏膜中的表达。结果 :p5 7kip2 蛋白阳性表达率在膀胱癌组织中为 4 6 % （2 3/ 5 0 ）

显著低于正常膀胱黏膜组织 78.6 % （11/ 14 ）（χ2 =4 .6 6 0

P <0 .0 5 ）

并与膀胱癌组织病理分级、生存率显著相关（χ2 =8.5 92

P <0 .0 5 ;χ2 =4 .5 4 6

P <0 .0 5 ）

但与临床分期无关（χ2 =0 .5 73

P >0 .0 5 ）。PCNA阳性表达率在膀胱癌组织中为 6 0 % （30 / 5 0 ）

显著高于正常膀胱黏膜组织的 0 % （0 / 14 ）（χ2 =15 .812

P <0 .0 1）

并与膀胱癌组织病理分级

临床分期和生存率显著相关（P <0 .0 5 ）。p5 7kip2 和PCNA蛋白的表达呈负相关（r =- 0 .4 4 3

P <0 .0 1）。结论 :p5 7kip2 的低表达与膀胱癌的发生发展密切相关

可以作为判断膀胱癌不良预后的参考指标。

Abstract

Objective:To assess the relation and clinical significance between p57 kip2 protein and the biological behavior of bladder transitional cell carcinoma(BTCC).Methods:The expression of p57 kip2 protein and PCNA was detected in 50 cases of BTCC

14 normal bladder mucosa by immunohistochemical method.Results:Positive rate of p57kip2 protein in BTCC was 46%

which was significant lower than 78.6% in normal bladder muscosa.( χ 2=4.660

P <0.05)

p57 kip2 protein expression correlated remarkably with both grade and survival ( χ 2=8.592

P <0.05; χ 2=4.546

P <0.05)

but did not correlate with clinical stage( χ 2=0.573

P >0.05);positive rate of PCNA in BTCC was 60 %(30/50)

which was significantly higher than 0%(0/14) in normal bladder mucosa( χ 2=15.812

P <0.01) PCNA expression correlated remarkably with both grade

stage and survival ( P <0.05).There was a highly significant inverse correlation between the expression of p57 kip2 protein and PCNA ( r =-0.443

P <0.01).Conclusion:The decreased expresson of p57 kip2 protein might closely related to the genesis and progression of BTCC

and it has a poor prognosis.

关键词

膀胱肿瘤细胞周期p57kip2蛋白增殖细胞核抗原

Keywords

bladder neoplasmcell cyclep57kip2 proteinPCNA

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Expression of p57kip2 protein in bladder transitionalcell carcinoma and its significance

DOI：10.13406/j.cnki.cyxb.2004.06.017

摘要

Abstract

关键词

Keywords

references

Expression of p57^kip2 protein in bladder transitionalcell carcinoma and its significance