Expression and significance of survivin in human breastinfiltrating duct carcinoma

MA Yinbin; et al

doi:10.13406/j.cnki.cyxb.2004.06.015

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Expression and significance of survivin in human breastinfiltrating duct carcinoma

更新时间：2024-01-17

- Expression and significance of survivin in human breastinfiltrating duct carcinoma
- Journal of Chongqing Medical University Issue 6, Pages: 759-761(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院普外科
  2. 重庆医科大学临床学院普外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.06.015
  CLC： R737.9
- Published：2004，
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[1]马银斌,吴诚义.Survivin在人乳腺浸润性导管癌中的表达及意义[J].重庆医科大学学报,2004(06):759-761+768.

MA Yinbin, et al. Expression and significance of survivin in human breastinfiltrating duct carcinoma. [J]. Journal of Chongqing Medical University (6):759-761(2004)
[1]马银斌,吴诚义.Survivin在人乳腺浸润性导管癌中的表达及意义[J].重庆医科大学学报,2004(06):759-761+768. DOI： 10.13406/j.cnki.cyxb.2004.06.015.

MA Yinbin, et al. Expression and significance of survivin in human breastinfiltrating duct carcinoma. [J]. Journal of Chongqing Medical University (6):759-761(2004) DOI： 10.13406/j.cnki.cyxb.2004.06.015.

摘要

目的 :探讨Survivin在人乳腺浸润性导管癌中的表达及临床意义。方法 :用原位杂交、免疫组化对人乳腺浸润性导管癌未化疗组 2 8例、化疗组 17例、癌旁正常组织 15例、乳腺良性病变 2 0例检测。结果 :每指标的SurvivinmRNA与Survivin蛋白表达无显著性差异且正相关 ;Survivin在人乳腺浸润性导管癌未化疗组表达高

不同年龄、TNM分期、病理分级、淋巴结转移、受体类型组间有显著性差异（P <0 .0 1） ;化疗组比未化疗组低（P <0 .0 1） ;在癌旁正常组织中无表达

在乳腺良性病变中低表达。结论 :Survivin在人乳腺浸润性导管癌高表达

有利于其诊断及疗效的判定。

Abstract

Objective:To investigate the expression and significance of survivin in human breast infiltrating duct carcinoma.Methods:In twenty-eight samples of human breast infiltrating duct carcinoma without chemotherapy

seventeen human breast infiltrating duct carcinoma with chemotherapy

fifteen human normal breast tissue adjacent to carcinoma

twenty breast benign lesion the expressions of survivin were determined by methods of in situ hybridization and immunohistochemistry.Results:The expressions of survivin mRNA were positively correlated with that of survivin protein in every marker and showed no significant difference.The positive expressions of survivin in human breast infiltrating duct carcinoma without chemotherapy were impressively high and they were significantly different among the ages

TNM stages

pathology grades

lymph node metastases and types of receptors( P <0.01).The expressions of survivin were lower in human breast infiltrating duct carcinoma with chemotherapy than without chemotherapy( P <0.01)

however

the expressions of survivin were not found in normal breast tissue and were very low in breast benign lesion.Conclusion:The expressions of survivin are rather high in human breast infiltrating duct carcinoma and may be helpful in diagnosis of the disease

and determination of the therapeutic effect.

关键词

Survivin乳腺肿瘤原位杂交免疫组化

Keywords

SurvivinBreast neoplasmsIn situ hybridizationimmunohistochemistry

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