Study on the relationship between serum creatine kinase level andpathological observation of tubal pregnancy

QI Hongbo; et al

doi:10.13406/j.cnki.cyxb.2004.06.013

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Study on the relationship between serum creatine kinase level andpathological observation of tubal pregnancy

更新时间：2024-01-17

- Study on the relationship between serum creatine kinase level andpathological observation of tubal pregnancy
- Journal of Chongqing Medical University Issue 6, Pages: 752-754(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院妇产科
  2. 重庆医科大学第二临床学院妇产科
  3. 重庆医科大学基础医学院病理学教研室,重庆,400016
  4. ,重庆,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.06.013
  CLC： R714.22
- Published：2004，
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[1]漆洪波,李玮,孙江川,卞度宏,曹友德,刘先俊.血清肌酸激酶水平与输卵管妊娠病理类型的关系[J].重庆医科大学学报,2004(06):752-754.

QI Hongbo, et al. Study on the relationship between serum creatine kinase level andpathological observation of tubal pregnancy. [J]. Journal of Chongqing Medical University (6):752-754(2004)
[1]漆洪波,李玮,孙江川,卞度宏,曹友德,刘先俊.血清肌酸激酶水平与输卵管妊娠病理类型的关系[J].重庆医科大学学报,2004(06):752-754. DOI： 10.13406/j.cnki.cyxb.2004.06.013.

QI Hongbo, et al. Study on the relationship between serum creatine kinase level andpathological observation of tubal pregnancy. [J]. Journal of Chongqing Medical University (6):752-754(2004) DOI： 10.13406/j.cnki.cyxb.2004.06.013.

摘要

目的 :探讨血清肌酸激酶（CK）水平与输卵管妊娠病理类型的关系。方法 :采用N -乙酰半胱氨酸（NAC）法

测定 2 2例破裂型输卵管妊娠患者和 35例未破裂型输卵管妊娠患者的血清CK水平

同时对输卵管妊娠组织标本进行病理分析。结果 :破裂型输卵管妊娠血清CK水平为（15 4 .2± 6 3.7）IU/L

高于未破裂型输卵管妊娠（10 7.8± 5 1.3）IU/L（P <0 .0 1）。输卵管峡部妊娠和壶腹部妊娠血清CK水平分别为（16 7.3± 4 5 .7）IU/L和（113.5± 5 4 .9）IU/L

两者比较

差异有显著性（P <0 .0 5 ）。滋养细胞管腔内生长型血清CK水平为（91.3± 4 3.7）IU/L

管腔外生长型及混合生长型血清CK水平为（12 8.5± 39.4 ）IU/L

两者比较

差异有显著性（P <0 .0 5 ）。以血清CK水平 135IU/L作为界值

预测输卵管妊娠破裂的敏感性为 77.2 %

特异性为82 .8%。结论 :血清CK测定可用于破裂型和未破裂型输卵管妊娠的鉴别诊断

对预测输卵管妊娠破裂有临床价值。

Abstract

Objective:To investigate the relationship between serum creatine kinase level and histopathological observation of tubal ectopic pregnancy.Methods:Serum creatine kinase was determined by N-acetyl cysteine(NAC) assay in 22 patients with ruptured tubal pregnancies and 35 patients with unruptured tubal pregnancies.Fallopian tube tissues were examined by histopathology.Results:The mean levels of serum creatine kinase in patients with ruptured tubal pregnancies were significantly higher than that in those with unruptured tubal pregnancies(154.2±63.7 IU/L vs 107.8±51.3 IU/L

P <0.01).Creatine kinase levels were higher in isthmic than ampullary ectopic pregnancies(167.3±45.7 IU/L vs 113.5±54.9 IU/L

P <0.05).The mean creatine kinase levels in unruptured tubal pregnancies with intraluminal trophoblastic growth were significantly lower than the levels in those with extraluminal and mixed trophoblastic growth (91.3±43.7 IU/L vs 128.5±39.4 IU/L

P <0.05).The cutoff value of creatine kinase to be used for the prediction of tubal rupture in ectopic pregnancy was 135 IU/L

which resulted in a sensitivity of 77.2% and specificity of 82.8%.Conclusion:Serum creatine kinase determination may help in discriminating ruptured tubal pregnancies from unruptured ones and prediction of tubal rupture in ectopic pregnancy.

关键词

妊娠输卵管组织病理肌酸激酶

Keywords

pregnancyTubalHistopathologyCreatine kinase

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