Immunohistochemical study of NF-κB signal transductionpathway in laryngeal carcinoma

ZHU Jiang; et al

doi:10.13406/j.cnki.cyxb.2004.06.012

您当前的位置：

首页 >

文章列表页 >

Immunohistochemical study of NF-κB signal transductionpathway in laryngeal carcinoma

更新时间：2024-01-17

- Immunohistochemical study of NF-κB signal transductionpathway in laryngeal carcinoma
- Journal of Chongqing Medical University Issue 6, Pages: 749-751(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院耳鼻咽喉科
  2. 山东省济宁医学院附属医院耳鼻咽喉科,重庆,400016
  3. ,山东,272129
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.06.012
  CLC： R739.65
- Published：2004，
扫描看全文
[1]朱江,胡国华,孙余才.喉癌NF-κB信号转导通路的免疫组化研究[J].重庆医科大学学报,2004(06):749-751+758.

ZHU Jiang, et al. Immunohistochemical study of NF-κB signal transductionpathway in laryngeal carcinoma. [J]. Journal of Chongqing Medical University (6):749-751(2004)
[1]朱江,胡国华,孙余才.喉癌NF-κB信号转导通路的免疫组化研究[J].重庆医科大学学报,2004(06):749-751+758. DOI： 10.13406/j.cnki.cyxb.2004.06.012.

ZHU Jiang, et al. Immunohistochemical study of NF-κB signal transductionpathway in laryngeal carcinoma. [J]. Journal of Chongqing Medical University (6):749-751(2004) DOI： 10.13406/j.cnki.cyxb.2004.06.012.

摘要

目的 :探讨NF -κB信号转导通路中的IKK、IκB、NF -κBP6 5在喉癌组织中的表达情况及意义。方法 :采用免疫组织化学染色S -P法检测 4 0例喉癌组织、2 0例正常喉粘膜组织的IKKα、IκBα、NF -κBP6 5的表达水平。结果 :喉癌组织中IKKα、NF -κBP6 5的表达水平明显高于正常组织

IκBα的表达水平明显低于正常组织（P <0 .0 5 ）。有颈淋巴结转移的喉癌组织中IKKα、NF -κBP6 5表达水平比无转移的喉癌组织表达明显增强

IκBα表达水平则明显下降（P <0 .0 5 ）。结论 :NF -κB信号转导通路可能在喉癌的发生、发展及转移中发挥重要作用。

Abstract

Objective:To explore the expression and significance of IKK

IκB and NF-κB P65 of NF-κ B signal transduction pathway in laryngeal carcinoma patients.Methods:The expression of IKKα

IκBα

NF-κB P65 was examined by immunohistochemical S-P method in laryngeal carcinoma tissues of 40 cases and normal laryngeal tissues of 20 cases.Results:The expression of IKKα and NF-κB P65 in laryngeal carcinoma tissue was higher compared with normal laryngeal tissue

while the expression of IκBα was lower( P <0.05).The expression of IKKα and NF-κB P65 in the carcinoma tissue with neck lymph node metastasis was higher than that without neck lymph node metastasis

but the expression of IκBα was lower ( P <0.05).Conclusion:NF-κB signal transduction pathway may play an important role in occurrence

development and metastasis of laryngeal carcinoma.

关键词

喉癌IKKIκBNF-κB免疫组织化学

Keywords

laryngeal carcinomaIKKIκ BNF-κ Bimmunohistochemistry

references

Views

197

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Clinical significance and expression of Ki-67 in laryngeal carcinoma

Expression and significance of NF-κB and ICAM-1 in laryngeal carcinoma

Correlation between expression of HPV16/18E6、cyclinD1、hTERT and development of laryngeal carcinoma

Expression and significance of FOXP3 in colon cancer cells

1,25-dihydroxyvitamin D₃ induced Hep-2 cells apoptosis through PI3K/AKT/Bcl-2 signaling pathway

Related Author

SUN Yucai

et al

朱江

ZHU Jiang

et al

孙余才

邓靖宇

LV Cai-feng

Related Institution

Department of Otolaryngology, College of Clinical Medicine, Chongqing Medical University

重庆医科大学临床学院耳鼻喉科

Department of Otorhinolaryngology,College of Clinical Medicine,Chongqing Medical University

重庆医科大学临床学院耳鼻咽喉科

Department of Otorhinolaryngology,the First Affiliated Hospital,Chongqing Medical University

⁰