Study of relationship between MUC1 and adhesion of breast cancer cells

LU Li; et al

doi:10.13406/j.cnki.cyxb.2004.06.010

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Study of relationship between MUC1 and adhesion of breast cancer cells

更新时间：2024-01-17

- Study of relationship between MUC1 and adhesion of breast cancer cells
- Journal of Chongqing Medical University Issue 6, Pages: 742-744(2004)
- 作者机构：
  
  1. 重庆医科大学基础医学院病理生理教研室
  2. 重庆医科大学基础医学院病理生理教研室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.06.010
  CLC： R737.9
- Published：2004，
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[1]鲁藜,邓华瑜,郑维萍,段红.MUC1与人乳腺癌细胞粘附能力关系的体外研究[J].重庆医科大学学报,2004(06):742-744.

LU Li, et al. Study of relationship between MUC1 and adhesion of breast cancer cells. [J]. Journal of Chongqing Medical University (6):742-744(2004)
[1]鲁藜,邓华瑜,郑维萍,段红.MUC1与人乳腺癌细胞粘附能力关系的体外研究[J].重庆医科大学学报,2004(06):742-744. DOI： 10.13406/j.cnki.cyxb.2004.06.010.

LU Li, et al. Study of relationship between MUC1 and adhesion of breast cancer cells. [J]. Journal of Chongqing Medical University (6):742-744(2004) DOI： 10.13406/j.cnki.cyxb.2004.06.010.

摘要

目的 :研究粘蛋白 1（MUC1）与人乳腺癌细胞粘附能力的关系。方法 :用苯甲基 -α -N -乙酰半乳糖胺处理人乳腺癌MDA -MB - 2 31高转移细胞株

免疫细胞化学法检测MUC1在处理前后的表达

以噻唑蓝比色法（MTT）法研究MUC1与肿瘤细胞的粘附能力的关系。结果 :苯甲基 -α -N -乙酰半乳糖胺能显著抑制肿瘤细胞MUC1表达而影响肿瘤细胞对Ma trigel的粘附（P <0 .0 1）。结论 :MUC1与肿瘤细胞的粘附能力密切相关

MUC1表达降低削弱肿瘤细胞的粘附能力。

Abstract

Objective:To investigate the effect of benzyl-α-GalNAc on MUC1 expression and the adhesion of breast cancer cell Iine(MDA-MB-231) so as to understand the relationship between MUC1 and invasiveness of human breast cancer cells.Methods:The activity and expression of MUC1 in breast cancer cells were detected with immunohistochemistry.The adhesive ability of those cells to various basement membrane components were measured by MTT assay.Results:Benzyl-α-GalNAc significantly suppressed the expression of MUC 1 and the adhesion of the tumor cell to basement membrane( P <0.01).Conclusion:There is a close relationship between MUC1 and adherence of breast cancer cells

and the MUC1 inhibitor significantly suppresses the adhesion capacity of MDA-MB-231 cell line in vitro.

关键词

粘蛋白1糖基化苯甲基-α-N-乙酰半乳糖胺乳腺癌细胞株粘附

Keywords

MUC1GlycosylationBenzyl-α-GalNAcBreast cancer cell lineAdhesion

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