Serum leptin concentrations in patients with chronic congestive heart failure

LI Gang; et al

doi:10.13406/j.cnki.cyxb.2004.05.022

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Serum leptin concentrations in patients with chronic congestive heart failure

更新时间：2024-01-17

- Serum leptin concentrations in patients with chronic congestive heart failure
- Journal of Chongqing Medical University Issue 5, Pages: 635-637(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院老年科
  2. 重庆医科大学第二临床学院核医学科
  4. ,重庆,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.05.022
  CLC： R541.6
- Published：2004，
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[1]李刚,严清波,魏良明.慢性心力衰竭患者血清瘦素水平[J].重庆医科大学学报,2004(05):635-637.

LI Gang, et al. Serum leptin concentrations in patients with chronic congestive heart failure. [J]. Journal of Chongqing Medical University (5):635-637(2004)
[1]李刚,严清波,魏良明.慢性心力衰竭患者血清瘦素水平[J].重庆医科大学学报,2004(05):635-637. DOI： 10.13406/j.cnki.cyxb.2004.05.022.

LI Gang, et al. Serum leptin concentrations in patients with chronic congestive heart failure. [J]. Journal of Chongqing Medical University (5):635-637(2004) DOI： 10.13406/j.cnki.cyxb.2004.05.022.

摘要

目的 :分析慢性心力衰竭（CHF）患者血清瘦素浓度变化。方法 :采用放射免疫平衡法检测 4 6例心功能NYHAⅠ级 :及 39例CHF患者（即心功能NYHAⅡ～Ⅳ级患者

心功能Ⅱ级 14例

Ⅲ级 2 1例

Ⅳ级 4例）血清瘦素浓度。结果 :血清瘦素浓度分别为 :心功能Ⅰ级组 14 .6 74± 6 .911μg/l;心功能Ⅱ级组 11.4 92± 5 .6 4 9μg/l;心功能Ⅲ级组 7.76 3± 3.32 1μg/l;心功能Ⅳ级组 6 .10 0± 2 .6 5 7μg/l;CHF组 9.0 18± 4 .5 19μg/l。与心功能Ⅰ级组比较

心功能Ⅲ级

Ⅳ级及CHF组血清瘦素浓度明显降低

具有统计学显著意义（t=2 .185～ 2 .786

P <0 .0 5 ） ;与心功能Ⅱ级比较

心功能Ⅲ级及心功能Ⅳ级组血清瘦素浓度亦明显降低

亦具有统计学显著差异（t=2 .6 0 5～ 2 .174

P <0 .0 5 ） ;各组中血清瘦素浓度降低与血清总胆固醇、甘油三酪、体重指数、左心室射血分数降低间的相关性呈显著统计学差异（r =0 .5 6 4～ 0 .999

P <0 .0 5 ）。结论 :CHF时血清瘦素浓度降低的意义尚待进一步探讨

Abstract

Objective:To explore the changes of serum leptin in chronic congestive heart failure(CHF).Methods:The serum levels of leptin in 46 patients with NYHA cardiac function class Ⅰ and in 39 patients with CHF(14 in class Ⅱ

21 in class Ⅲ and 4 in class Ⅳ)were assessed by radioimmunoassay.Results:The serum contents of leptin were 11.674±6.911μg/l in NYHA class Ⅰ group

11.492±5.649 μg/l in classⅡ group

7.763±3.321 μg/l in class Ⅲ group

6.100± 2.657 μg/l in class Ⅳ group and 9.018±4.519 μg/l in CHF group.The serum levels of leptin were significantly lower in class Ⅲ group

class Ⅳ group and CHF group

compared with class Ⅰ group

respectively( t =2.185～2.786

P <0.05).Compared with class Ⅱ group

the levels of leptin were also significantly lower in class Ⅲ group and class Ⅳ group

respectively( t =2.605～2.174

P <0.05).The decrease of serum leptin level was significantly correlated with the decreased serum total cholesterol level

triglyceride

body mass index and left ventricular ejection fraction in all groups

respectively( r =0.564～0.999

P <0.05).Conclusion:The role of the decreased serum leptin in CHF remains to be studied.

关键词

心力衰竭瘦素冠心病

Keywords

Congestive heart failureleptincoronary heart disease

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Related Institution

Department of General Medicine，The Second Affiliated Hospital of Chongqing Medical University

Department of Ultrasound，Yichang Central People's Hospital，The First College of Clinical Medical Science，China Three Gorges University

Department of Clinical Research Center,The First Affiliated Hospital of Chongqing Medical University

重庆医科大学临床学院心内科

Department of Cardiology,College of Clinical Medicine,Chongqing Medical University

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