The expression of cyclin kinase inhibitor P21<sup>WAF1</sup>  and P27<sup>KIP1</sup> in children with acute lymphoblastic leukemia

SU Yongchun; et al

doi:10.13406/j.cnki.cyxb.2004.05.021

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The expression of cyclin kinase inhibitor P21^WAF1 and P27^KIP1 in children with acute lymphoblastic leukemia

更新时间：2024-01-17

- The expression of cyclin kinase inhibitor P21^WAF1 and P27^KIP1 in children with acute lymphoblastic leukemia
- Journal of Chongqing Medical University Issue 5, Pages: 632-634(2004)
- 作者机构：
  
  1. 重庆医科大学儿科学院血液科
  2. 重庆医科大学儿科学院血液科,重庆,400014
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.05.021
  CLC： R733.7
- Published：2004，
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[1]苏庸春,徐酉华,于洁,刘筱梅,宪莹.儿童急性淋巴细胞白血病P21~(WAF1)、P27~(KIP1)蛋白表达及其临床意义[J].重庆医科大学学报,2004(05):632-634.

SU Yongchun, et al. The expression of cyclin kinase inhibitor P21^WAF1 and P27^KIP1 in children with acute lymphoblastic leukemia. [J]. Journal of Chongqing Medical University (5):632-634(2004)
[1]苏庸春,徐酉华,于洁,刘筱梅,宪莹.儿童急性淋巴细胞白血病P21~(WAF1)、P27~(KIP1)蛋白表达及其临床意义[J].重庆医科大学学报,2004(05):632-634. DOI： 10.13406/j.cnki.cyxb.2004.05.021.

SU Yongchun, et al. The expression of cyclin kinase inhibitor P21^WAF1 and P27^KIP1 in children with acute lymphoblastic leukemia. [J]. Journal of Chongqing Medical University (5):632-634(2004) DOI： 10.13406/j.cnki.cyxb.2004.05.021.

摘要

目的 :探讨细胞周期蛋白依赖性激酶抑制因子P2 1WAF1、P2 7KIP1在儿童急性淋巴细胞白血病（ALL）的表达情况及意义。方法 :采用免疫细胞化学S -P染色法测定骨髓单个核细胞P2 1WAF1、P2 7KIP1表达情况

分别观察阳性率及阳性细胞积分。结果 :P2 1WAF1、P2 7KIP1阳性率及在阳性病例中的阳性细胞积分均低于对照组（P <0 .0 5 ）

随访部分病例

经诱导化疗达到完全缓解后

两种蛋白有阳转或表达增强现象

治疗前后两种蛋白阳性率及阳性细胞积分均有显著性差异（P <0 .0 5 ）。结论 :P2 1WAF1、P2 7KIP1在儿童急性淋巴细胞白血病表达减低

可作为其化疗疗效的分子学指标。

Abstract

Objective:To probe the expression of P21 WAF1 and P27 KIP1 in children with acute lymphoblastic leukemia (ALL) and its clinical significance.Methods:The method of immunocytochemistry is used to estimate the expression of P21 WAF1 and P27 KIP1 .Both percentage and intensity of positive cells were counted.Results:The results showed that the positive ratio of P21 WAF1 in ALL samples was 9.1% (2/22) and P27 KIP1 was 50%(11/22).The trends of higher expression of P21 WAF1 and P27 KIP1 were noted in follow-up study on eight patients with ALL.Most of the P27 KIP1 positive cells were pigmented in nucleus in the control group while pigmented in both nucleus and plasma in the studied patients.Conclusion:P21 WAF1

P27 KIP1 may be a marker for evaluation of therapeutic effects.

关键词

白血病细胞周期蛋白依赖性激酶抑制因子儿童细胞周期

Keywords

leukemiaCyclin kinase inhibitorchildcell cycle

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The expression of cyclin kinase inhibitor P21WAF1 and P27KIP1 in children with acute lymphoblastic leukemia

DOI：10.13406/j.cnki.cyxb.2004.05.021

摘要

Abstract

关键词

Keywords

references

The expression of cyclin kinase inhibitor P21^WAF1 and P27^KIP1 in children with acute lymphoblastic leukemia