Intraocular penetration of levofloxacin in rabbit eyes following topical and subconjunctival administration

SUN Hang; et al

doi:10.13406/j.cnki.cyxb.2004.05.019

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Intraocular penetration of levofloxacin in rabbit eyes following topical and subconjunctival administration

更新时间：2024-01-17

- Intraocular penetration of levofloxacin in rabbit eyes following topical and subconjunctival administration
- Journal of Chongqing Medical University Issue 5, Pages: 625-628(2004)
- 作者机构：
  
  1. 重庆医科大学病毒性肝炎研究所
  2. 重庆医科大学第二临床学院眼科
  3. 重庆医科大学临床学院临床药理教研室
  5. ,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.05.019
  CLC： R969.1
- Published：2004，
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[1]孙航,杨淑群,周远大,何海霞.左旋氧氟沙星滴眼及球结膜下注射的兔眼通透性比较[J].重庆医科大学学报,2004(05):625-628.

SUN Hang, et al. Intraocular penetration of levofloxacin in rabbit eyes following topical and subconjunctival administration. [J]. Journal of Chongqing Medical University (5):625-628(2004)
[1]孙航,杨淑群,周远大,何海霞.左旋氧氟沙星滴眼及球结膜下注射的兔眼通透性比较[J].重庆医科大学学报,2004(05):625-628. DOI： 10.13406/j.cnki.cyxb.2004.05.019.

SUN Hang, et al. Intraocular penetration of levofloxacin in rabbit eyes following topical and subconjunctival administration. [J]. Journal of Chongqing Medical University (5):625-628(2004) DOI： 10.13406/j.cnki.cyxb.2004.05.019.

摘要

目的 :比较左旋氧氟沙星（LVFX）点眼和球结膜下注射后家兔眼各组织的药物浓度及药代动力学参数。方法 :将 0 .3%LVFX滴入或球结膜下注射入兔眼

在不同时点取角膜、房水、虹膜 -睫状体、晶状体、玻璃体等组织

用高效液相色谱法测定组织中的药物浓度。结果 :球结膜下注射LVFX后

不但在角膜、虹膜 -睫状体中具有更高的药物浓度

而且在晶状体和玻璃体内也有较高的药物浓度

与滴眼组相比较

有显著差异（P <0 .0 1或P <0 .0 5 ）。结论 :球结膜下注射LVFX较滴入法更有利于治疗严重的眼部感染

Abstract

Objective:To compare the ocular tissue concentrations and pharmacokinetic parameters in rabbit’s eyes after topically and subconjunctivally administrated with levofloxacin (LVFX).Methods:The concentrations of LVFX in the cornea

aqueous humor

iris-ciliary body

lens and vitreous at different times were measured by high performance liquid chromatography after 0.3% LVFX were topically and subconjunctivally administrated into rabbits.Results:The penetration of LVFX into the cornea

iris-ciliary body

lens and vitreous after subconjunctival injection was significantly higher than that of topically applied one( P <0.01 or P <0.05).Conclusion:Subconjunctival LVFX could be more effective than topical administration in the treatment of severe eye infection.

关键词

左旋氧氟沙星药物分布药代动力学高效液相色谱法

Keywords

LevofloxacinDrug distributionpharmacokineticshigh performance liquid chromatography

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