Establishment of hyperinsulinemic euglycemic clamp technique

WANG Zhihong; et al

doi:10.13406/j.cnki.cyxb.2004.05.016

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Establishment of hyperinsulinemic euglycemic clamp technique

更新时间：2024-01-17

- Establishment of hyperinsulinemic euglycemic clamp technique
- Journal of Chongqing Medical University Issue 5, Pages: 615-617(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院内分泌科
  2. 重庆市急救中心内科
  3. 重庆医科大学临床学院内分泌科,重庆,400016
  4. ,重庆,400012
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.05.016
  CLC： R587.1
- Published：2004，
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[1]汪志红,李启富,张素华,刘秀容,刘智萍,罗四川,黄健康,何军.高胰岛素-正葡萄糖钳夹技术的建立[J].重庆医科大学学报,2004(05):615-617.

WANG Zhihong, et al. Establishment of hyperinsulinemic euglycemic clamp technique. [J]. Journal of Chongqing Medical University (5):615-617(2004)
[1]汪志红,李启富,张素华,刘秀容,刘智萍,罗四川,黄健康,何军.高胰岛素-正葡萄糖钳夹技术的建立[J].重庆医科大学学报,2004(05):615-617. DOI： 10.13406/j.cnki.cyxb.2004.05.016.

WANG Zhihong, et al. Establishment of hyperinsulinemic euglycemic clamp technique. [J]. Journal of Chongqing Medical University (5):615-617(2004) DOI： 10.13406/j.cnki.cyxb.2004.05.016.

摘要

目的 :建立高胰岛素 -正常葡萄糖钳夹技术。方法 :应用高胰岛素 -正常葡萄糖钳夹技术对 8例正常体重、正常糖耐量者进行了方法学的研究。结果 :在优势胰岛素浓度、血浆葡萄糖浓度稳定在正常空腹水平状态下

内源性胰岛素释放和肝糖产生被抑制

升糖激素（皮质醇、生长激素、胰高糖素）无明显增高。（2 ）在高胰岛素 -正常葡萄糖钳夹稳态期

葡萄糖利用率为 9.2 5± 0 .2 5mg/（kg .min）。结论 :高胰岛素 -正常葡萄糖钳夹技术已成功建立。在外源性胰岛素 -葡萄糖代谢的稳定状态下

机体葡萄糖利用率显著增加

Abstract

Objective:To establish a hyperinsulinemic euglycemic clamp technique for the study of insulin sensitivity in Chinese.Methods:A hyperinsulinemic euglycemic clamp technique was used to the study of methodology in 8 normal weight subjects with normal glucose tolerance.Results:(1)When a higher level of insulin was created during maintaining fasting euglycemia

the secretion of endogenous insulin and hepatic glucose production were completely inhibited.The secretion of counter-regulatory hormones(cortisol

growth hormone and glucagon) was not significantly stimulated..(2)During the steady-state of hyperinsulinemic euglycemic clamp

the glucose disposal rate was 9.25±0.25mg/(kg.min)Conclusion:The hyperinsulinemic euglycemic clamp technique was established successfully in Chinese.During the steady-state of exogenous insulin and glucose metabolism

glucose utilization increased.

关键词

高胰岛素-正葡萄糖钳夹技术胰岛素抵抗胰岛素敏感性

Keywords

Hyperinsulinemic euglycemic clamp techniqueinsulin resistanceinsulin sensitivity

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