Relationship between expression of cyclooxygenase-2 and proliferation and apoptosis in esophageal carcinoma

WANG Shunwen; et al

doi:10.13406/j.cnki.cyxb.2004.05.011

您当前的位置：

首页 >

文章列表页 >

Relationship between expression of cyclooxygenase-2 and proliferation and apoptosis in esophageal carcinoma

更新时间：2024-01-17

- Relationship between expression of cyclooxygenase-2 and proliferation and apoptosis in esophageal carcinoma
- Journal of Chongqing Medical University Issue 5, Pages: 597-600(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院消化内科
  2. 重庆医科大学临床学院消化内科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.05.011
  CLC： R735.1
- Published：2004，
扫描看全文
[1]王顺文,高青,王丕龙.环氧化酶-2的表达与食管癌细胞增殖和凋亡的关系[J].重庆医科大学学报,2004(05):597-600.

WANG Shunwen, et al. Relationship between expression of cyclooxygenase-2 and proliferation and apoptosis in esophageal carcinoma. [J]. Journal of Chongqing Medical University (5):597-600(2004)
[1]王顺文,高青,王丕龙.环氧化酶-2的表达与食管癌细胞增殖和凋亡的关系[J].重庆医科大学学报,2004(05):597-600. DOI： 10.13406/j.cnki.cyxb.2004.05.011.

WANG Shunwen, et al. Relationship between expression of cyclooxygenase-2 and proliferation and apoptosis in esophageal carcinoma. [J]. Journal of Chongqing Medical University (5):597-600(2004) DOI： 10.13406/j.cnki.cyxb.2004.05.011.

摘要

目的 :研究食管癌环氧化酶 - 2 （COX - 2 ）的表达与增殖细胞核抗原以及凋亡的关系。方法 :采用免疫组化方法检测96例食管癌组织和 2 0例对照组中的COX - 2、bcl- 2和PCNA

同时用末端脱氧核苷酸转移介导的dUTP缺口末端标记法（TUNEL法）进行原位凋亡检测

并计算增殖指数（proliferationindexPI）和凋亡指数（apoptoticindexAI）。结果 :96例食管癌组织中的COX - 2和bcl- 2表达升高

PI为 72 .2 0 %

AI为 8.6 7%

COX - 2、PI和AI与肿瘤的淋巴结转移、血管的浸润以及临床分期密切相关。结论 :COX - 2通过上调bcl- 2促进肿瘤细胞增殖和抑制细胞凋亡参与了食管癌的发生机理

Abstract

Objective:To study the relationship between the expression of cyclooxygenase-2 and proliferation and apoptosis in esophageal carcinoma.Methods:A total of 96 patients and 20 control patients were studied

the expression of COX-2 and bcl-2 and PCNA were examined by immunohistochemistry

the apoptosis was determined by counting the number of cells labeled by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL)method.The proliferation index(PI) and apoptotic index(AI) were calculated.Results:Expression of COX-2 and bcl-2 in carcinoma tissue were significantly higher than those in normal control tissue( P <0.05).Expression of AI in carcinoma tissue was significantly lower than those in normal control tissue.Expression of COX-2 and PI were highly correlated with lymph node metastasis and vascular invasion and stage of cancer.Conclusion:COX-2 can enhance the cell proliferation and suppress apoptosis and induce the esophageal carcinoma by up-regulated bcl-2.

关键词

食管癌环氧化酶-2增殖细胞核抗原凋亡

Keywords

esophageal carcinomaCyclooxygenase-2Proliferating cellnuclear antigenApotosis

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Association of NUSAP1 with tumor cell proliferation and immune cell infiltration in esophageal carcinoma: database based research

Meta-analysis on the relationship between cyclooxygenase-2 gene polymorphism and gastric cancer in Asian population

A role of sodium selenite in regulating expression of Cyclooxygenase-2(COX-2) mRNA in rat mesangial cells

Comparison between DDP and CMNa in radiosensitivity enhancement for patients with intermediate and advanced esophageal carcinoma

Study of NS398 reversing the antergy of lysophosphatidic acid for the inhibiting effect of cisplatin in the proliferation of huanman ovarian cancer

Related Author

Sun Xue

Li Zhongcheng

Bai Chengyun

Li Wenjun

Liu Yang

Tan Wei

Ren Mengjun

Wen Jing

Related Institution

Department of Thoracic Surgery，Affiliated Hospital of Qinghai University

Department of Gastroenterology,the Third People’s Hospital of Chongqing

Sweden

Karolinska Institute Stockholm

Department of Molecular Medicine

⁰