The clinical study of topiramate on Tourette’s syndrome

XIAO Nong; et al

doi:10.13406/j.cnki.cyxb.2004.04.041

您当前的位置：

首页 >

文章列表页 >

The clinical study of topiramate on Tourette’s syndrome

更新时间：2024-01-17

- The clinical study of topiramate on Tourette’s syndrome
- Journal of Chongqing Medical University Issue 4, Pages: 531-533(2004)
- 作者机构：
  
  1. 重庆医科大学儿科学院神经内科
  2. 重庆市急救中心内科,重庆,400014
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.04.041
  CLC： R749.94
- Published：2004，
扫描看全文
[1]肖农,王俐.妥泰治疗多发性抽动症临床研究[J].重庆医科大学学报,2004(04):531-533.

XIAO Nong, et al. The clinical study of topiramate on Tourette’s syndrome. [J]. Journal of Chongqing Medical University (4):531-533(2004)
[1]肖农,王俐.妥泰治疗多发性抽动症临床研究[J].重庆医科大学学报,2004(04):531-533. DOI： 10.13406/j.cnki.cyxb.2004.04.041.

XIAO Nong, et al. The clinical study of topiramate on Tourette’s syndrome. [J]. Journal of Chongqing Medical University (4):531-533(2004) DOI： 10.13406/j.cnki.cyxb.2004.04.041.

摘要

目的 :观察妥泰治疗儿童多发性抽动症的疗效及其副作用。方法 :将多发性抽动症 112例患儿随机分为治疗组和对照组各 5 6例。治疗组采用妥泰按 1～ 2mg/（kg·d）每日 2次吞服

对照组采用氟哌啶醇 1～ 6mg/d

每日分 2～ 3次口服。治疗期间每月定期门诊复诊。结果 :治疗组有效率为 83.92 %

对照组有效率为 80 .35 %。两组有效率比较差异无显著性（χ2 =0 .0 6 1

P >0 .0 5 ） ;两组副作用相比有极显著差异（χ2 =4 9.86 3

P <0 .0 0 0 1）。结论 :妥泰与氟哌啶醇治疗TS同样有效

但副作用较氟哌啶醇明显减少

同时可有效减轻合并症状

Abstract

Objective:To observe the efficacy and side effects of Topiramate(TPM) on children with Tourette’s syndrome(TS).Methods:112 children with Tourcttc’s syndrome (TS) were randomly divided into two groups

namely the routine group and control group.56patients of routine group were treated with Topiramate

while the others in control group were treated with haloperidol.Patients in the former group took Topiramte 1～2mg/(kg·d) twice per day while those of the latter group took haloperidol 1～6mg/d twice or three times per day.The patients were assessed by regular return visits every month during the period of receiving trcatment.Results:The efficacy rates of two groups were 83.92% and 80.35% respectively with no significant differences found between two groups(x~2=0.061 P>0.05).However there existed great differences in their side effects(x~2=49.863 P<0.0001).Conclusion:The study indicates that both Topiramatc and haloperidol are effective in treating Tourette’s syndrome.However as far as the side effects are concerned

the Topirimate is more efficient than haloperidol for alleviating the complications.

关键词

妥泰多发性抽动症治疗

Keywords

TopiramatcTourette’s syndrometherapy

references

Views

145

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Research advances of ERRα nuclear receptor transcription factor in cancer development and progression

Investigation on the status of anti-HCV treatment knowledge among doctors from China’s mainland

OBSERVATIONS ON THE TREATMENT OF ADVANCED GASTRIC CANCER WITH TRANSFER FACTOR

Therapy of depressive symptoms in the elderly

Comparative study of the effect and side-effects of common and small dose amiodarone on cardioversion for atrial fibrillation

Related Author

Liu Jiahui

Huang Ling

Sun Zhaohui

Zhou Quan

Duan Zhongping

Zheng Shuju

Chen Yu

Liu Mei

Related Institution

Laboratory of Basic Medical Science,General Hospital of Southern Theater Command of PLA

Department of Laboratory Medicine,General Hospital of Southern Theater Command of PLA

Department of Liver,Wu Jie Ping Medical Foundation

Artificial Liver Center,Beijing Youan Hospital,Capital Medical University

重庆医科大学第一医院外科教研室重庆医科大学第一医院外科实验室

⁰