The effect of valsartan on TNF-α production in patients with congestive heart failure

CHEN Qihong; et al

doi:10.13406/j.cnki.cyxb.2004.04.033

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The effect of valsartan on TNF-α production in patients with congestive heart failure

更新时间：2024-01-17

- The effect of valsartan on TNF-α production in patients with congestive heart failure
- Journal of Chongqing Medical University Issue 4, Pages: 511-512(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院心血管内科
  2. 重庆医科大学临床学院心血管内科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.04.033
  CLC： R541.6
- Published：2004，
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[1]陈齐红,覃数,汪华玲.缬沙坦在体外对充血性心力衰竭患者血清TNF-α的影响[J].重庆医科大学学报,2004(04):511-512+520.

CHEN Qihong, et al. The effect of valsartan on TNF-α production in patients with congestive heart failure. [J]. Journal of Chongqing Medical University (4):511-512(2004)
[1]陈齐红,覃数,汪华玲.缬沙坦在体外对充血性心力衰竭患者血清TNF-α的影响[J].重庆医科大学学报,2004(04):511-512+520. DOI： 10.13406/j.cnki.cyxb.2004.04.033.

CHEN Qihong, et al. The effect of valsartan on TNF-α production in patients with congestive heart failure. [J]. Journal of Chongqing Medical University (4):511-512(2004) DOI： 10.13406/j.cnki.cyxb.2004.04.033.

摘要

目的 :检测充血性心力衰竭（CHF）患者血清肿瘤坏死因子 -α（TNF -α）、一氧化氮（NO）的浓度变化 ;观察缬沙坦对CHF患者外周血单个核细胞（PBMC）分泌TNF -α、NO的影响

探讨缬沙坦治疗CHF的细胞因子机制。方法 :12例Ⅲ—Ⅳ级的CHF患者静脉血离心取PBMC

分别加入缬沙坦和脂多糖

使缬沙坦终浓度为（0、0 .0 1、0 .1、1） μmol/L

经 2 4h孵化后

检测培养上清液中TNF -α、NO的浓度。结果 :CHF患者血清TNF -α、NO显著高于对照组（P <0 .0 1）。心功能Ⅳ级组明显高于心功能Ⅲ级（P <0 .0 1）。不同病因CHF患者之间TNF -α、NO差异无显著性。不同浓度的缬沙坦对正常人和CHF组PBMC分泌TNF -α、NO均有抑制作用

且随着缬沙坦浓度的升高

TNF -α、NO的分泌呈下降趋势。结论 :CHF的程度与TNF -α、NO浓度的相关程度提示TNF -α、NO在CHF的发生和发展中起重要作用

缬沙坦能够直接抑制PBMC分泌TNF -α、NO

可能是血管紧张素Ⅱ受体拮抗剂治疗CHF的细胞因子机制之一。

Abstract

Objective:To examine the change of serum tumor necrosis-α (TNF-α)

nitric oxide (NO) in patients with congestive heart failure(CHF) in vitro and the effect of valsartan on TNF-α production in peripheral blood mononuclear cell(PBMC)

and to assess the mechanisms of valsartan in treating CHF.Methods:Venous blood sumples were obtained from both CHF patients (n=12) and healthy volunteers(n=8).Serum TNF-α and NO were measured.PBMC was obtained from both the control and the patient groups.PBMC were cultured with 0

0.01

0.1

1 μmol/L of valsartan in the presence of lipopolysaccharide.After 24 hours’ incubation

TNF-α and NO were measured in the culture supernatants.Results:Serum TNF-α and NO were significantly higher than these of the control group(P<0.01)

and the higher the heart failure degree

the higher the levels of the cytokines(P<0.01).Valsartan inhibited TNF-α and NO production in a concentration-dependent manner.Conclusion:TNF-α plays an important role in the development of CHF.The fact that valsartan inhibits TNF-α production in PBMC may be one of mechanisms in treating CHF by ARB.

关键词

充血性心力衰竭TNF-αNO缬沙坦

Keywords

Congestive heart failureTNF-αNOvalsartan

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