A DNBS-induced model of ulcerative colitis in rats

ZHU Daihua; et al

doi:10.13406/j.cnki.cyxb.2004.04.024

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A DNBS-induced model of ulcerative colitis in rats

更新时间：2024-01-17

- A DNBS-induced model of ulcerative colitis in rats
- Journal of Chongqing Medical University Issue 4, Pages: 486-487(2004)
- 作者机构：
  
  1. 重庆医科大学第二临床学院普外科
  2. 重庆医科大学第二临床学院普外科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.04.024
  CLC： R-332
- Published：2004，
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[1]朱代华,张兴明,郭丹.二硝基苯磺酸诱导的鼠溃疡性结肠炎动物模型[J].重庆医科大学学报,2004(04):486-487+490.

ZHU Daihua, et al. A DNBS-induced model of ulcerative colitis in rats. [J]. Journal of Chongqing Medical University (4):486-487(2004)
[1]朱代华,张兴明,郭丹.二硝基苯磺酸诱导的鼠溃疡性结肠炎动物模型[J].重庆医科大学学报,2004(04):486-487+490. DOI： 10.13406/j.cnki.cyxb.2004.04.024.

ZHU Daihua, et al. A DNBS-induced model of ulcerative colitis in rats. [J]. Journal of Chongqing Medical University (4):486-487(2004) DOI： 10.13406/j.cnki.cyxb.2004.04.024.

摘要

目的 :建立一种由 2

4 -二硝基苯磺酸（DNBS）诱导的溃疡性结肠炎（UC）动物模型。方法 :用 18%的DNBS乙醇溶液 0 .2 5ml灌肠

在Wistar大鼠上建立UC模型。结果 :DNBS/乙醇灌肠后

实验鼠出现血性腹泻

持续 2～ 3天

而粘液性腹泻持续时间长达 2 1天。结肠病理表现为充血、水肿、局限于粘膜内的溃疡、杯状细胞排空、隐窝脓肿等。结论 :DNBS/乙醇诱导的鼠UC模型类似于人UC

具有操作简单、重复性好、毒性小、价廉的优点

Abstract

Objective:To build the model of ulcerative colitis(UC) induced by 2

4-dinitrobenzenesulfonic acid (DNBS).Methods:The experimental UC was induced in Wistar rats by enema with 0.25ml of 18% DNBS dissolved in ethanol.Results:DNBS caused severe diarrhea with colorectal bleeding for 2～3 days and mucous diarrhea for 21 days.The pathologic changes of the colon included hyperemia

edema

ulcerations localized in colonic mucosa

depletion of goblet cells and formation of crypt abscess.Conclusion:The DNBS-induced model of UC in rats is similar to human UC

and has such advantages as easy replication

low toxicity and cheapness.

关键词

溃疡性结肠炎疾病模型动物鼠

Keywords

ulcerative colitisdisease modelAnimalRat

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