A randomized comparative study of gatifloxacin and levofloxacin injection in the treatment of bacterial infections

YU Zebo; et al

doi:10.13406/j.cnki.cyxb.2004.04.023

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A randomized comparative study of gatifloxacin and levofloxacin injection in the treatment of bacterial infections

更新时间：2024-01-17

- A randomized comparative study of gatifloxacin and levofloxacin injection in the treatment of bacterial infections
- Journal of Chongqing Medical University Issue 4, Pages: 482-485(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院感染科
  2. 北京大学临床药理研究所
  3. 重庆医科大学临床学院感染科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.04.023
  CLC： R515
- Published：2004，
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[1]余泽波,肖永红,蔡素芳,李崇智,刘鸿渝.甲磺酸加替沙星葡萄糖注射液与左氧氟沙星注射液治疗细菌性感染临床疗效观察[J].重庆医科大学学报,2004(04):482-485.

YU Zebo, et al. A randomized comparative study of gatifloxacin and levofloxacin injection in the treatment of bacterial infections. [J]. Journal of Chongqing Medical University (4):482-485(2004)
[1]余泽波,肖永红,蔡素芳,李崇智,刘鸿渝.甲磺酸加替沙星葡萄糖注射液与左氧氟沙星注射液治疗细菌性感染临床疗效观察[J].重庆医科大学学报,2004(04):482-485. DOI： 10.13406/j.cnki.cyxb.2004.04.023.

YU Zebo, et al. A randomized comparative study of gatifloxacin and levofloxacin injection in the treatment of bacterial infections. [J]. Journal of Chongqing Medical University (4):482-485(2004) DOI： 10.13406/j.cnki.cyxb.2004.04.023.

摘要

目的 :评价国产甲磺酸加替沙星葡萄糖注射液治疗呼吸道感染及泌尿道感染的疗效与安全性。方法 :2 5例患者接受甲磺酸加替沙星葡萄糖液 2 0 0mg

静脉滴注

每日 2次 ;2 5例接受左氧氟沙星注射液 2 0 0mg

静脉滴注

每日 2次

疗程 5～14天。结果 :试验组和对照组痊愈率和有效率分别为 6 4 %、5 6 % （P >0 .0 5 ）与 92 %、88% （P >0 .0 5 ）。两组的细菌阳性率、消除率分别为 96 %、10 0 %和 6 8%、10 0 %。临床分离的 4 1株致病菌对甲磺酸加替沙星、左氧氟沙星、环丙沙星、司帕沙星、头孢噻肟的敏感率分别为 10 0 %、95 .12 %、95 .12 %、92 .6 8%、97.5 6 %

无显著性差异（P >0 .0 5 ）。两组不良反应发生率分别为30 .77%和 2 0 %

无显著性差异（P >0 .0 5 ）。结论 :甲磺酸加替沙星葡萄糖液治疗中、重度细菌感染安全、有效

Abstract

Objective:To evaluate the clinical efficacy and safety of gatifloxacin injection in the treatment of moderate and severe bacterial infections.Methods:25 patients in study group were treated with gatifloxacin 200mg iv q12h and 25 patients in control group with levofloxacin 200mg iv q12h for 5 to 14 days.Results:The cure rates and the effective rates of the two groups were 64%

56%(P>0.05) and 92%

88%(P>0.05)

respectively.The bacterial positive and eradication rates of the two groups were 96%

68% and 100%

100%

respectively.Sensitivity rates of 41 bacterial strains to gatifloxacin

levofloxacin

ciprofloxacin

sparfloxacin

cefataxime were 100%

95.12%

92.68%

97.56%

respectively.Adverse events were generally mild.Adverse events rates of the two groups were 30.77% and 20%(P>0.05)

respectively.Conclusion:Gatifloxacin injection is a highly effective and well tolerated antibacterial agent for the treatment of moderate and severe bacterial infections.

关键词

甲磺酸加替沙星左氧氟沙星临床疗效细菌性感染

Keywords

GatifloxacinLevofloxacinClinical trialBacterial infections

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