Correlation study of neurologic functional rehabilitation and concentrations of serum and cerebrospinal fluid C-reactive protein in patients with acute cerebral infarction

WANG Zhenhai; et al

doi:10.13406/j.cnki.cyxb.2004.04.019

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Correlation study of neurologic functional rehabilitation and concentrations of serum and cerebrospinal fluid C-reactive protein in patients with acute cerebral infarction

更新时间：2024-01-17

- Correlation study of neurologic functional rehabilitation and concentrations of serum and cerebrospinal fluid C-reactive protein in patients with acute cerebral infarction
- Journal of Chongqing Medical University Issue 4, Pages: 471-473(2004)
- 作者机构：
  
  1. 宁夏医学院附属医院干部病房
  2. 重庆医科大学神经病研究所
  3. 宁夏医学院附属医院干部病房,宁夏,银川市,750004
  4. ,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.04.019
  CLC： R743.3
- Published：2004，
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[1]王振海,方永鹏,谢鹏,孔繁元,潘月英.C-反应蛋白对初发急性脑梗死患者神经功能康复预测的相关性研究[J].重庆医科大学学报,2004(04):471-473.

WANG Zhenhai, et al. Correlation study of neurologic functional rehabilitation and concentrations of serum and cerebrospinal fluid C-reactive protein in patients with acute cerebral infarction. [J]. Journal of Chongqing Medical University (4):471-473(2004)
[1]王振海,方永鹏,谢鹏,孔繁元,潘月英.C-反应蛋白对初发急性脑梗死患者神经功能康复预测的相关性研究[J].重庆医科大学学报,2004(04):471-473. DOI： 10.13406/j.cnki.cyxb.2004.04.019.

WANG Zhenhai, et al. Correlation study of neurologic functional rehabilitation and concentrations of serum and cerebrospinal fluid C-reactive protein in patients with acute cerebral infarction. [J]. Journal of Chongqing Medical University (4):471-473(2004) DOI： 10.13406/j.cnki.cyxb.2004.04.019.

摘要

目的 :根据发病或入院时血清和脑脊液C反应蛋白（CRP）浓度预测初发急性脑梗死患者出院时的神经功能康复。方法 :本实验将 4 6例初发急性脑梗死住院患者作为观察组

2 5例与观察组相匹配的骨折、阑尾或胆囊摘除手术病人以及健康体检者作为对照组 ;检测其血液及脑脊液CRP的含量 ;并应用SPSS 10 .0统计软件包进行统计学分析 ;结果 :ACI患者血液和脑脊液CRP显著高于恢复期患者和对照组（P <0 .0 1） ;血液和脑脊液NSE含量与出院时神经功能缺损程度呈显著正相关（P<0 .0 1） ;结论 :脑脊液或血清中的CRP浓度

反映了神经元的损害程度

也是脑组织破坏后较合适的生化标记物 ;有助于预测初发脑梗死患者出院时神经功能康复

也可以作为筛选早期康复对象的依据

Abstract

Objective:To evaluate the clinical value of determinations of C-reactive protien concentration in serum and cerebrospinal fluid from patients with acute and recovery cerebral infarction and to find out the correlation of it with neurologic deficits

infarct sige and duration.Methods:46 cases of patients with cerebral infarction were recruited as observe group and 25 cases of healthy examinees or patients undergoing operation of fracture

appendix or cholecyst ectomy were recruited as control group.We measured C-reactive protien in cerebrospinal fluid and serum.Comparison analysis was performed using a SPSS10.0 statistical package.Results:Concentration of C-reactive protien in cerebrospinal fluid and serum was significantly higher in patients with cerebral infarction than that in patients at recovery stage and control group(P<0.01).Level of C-reactive protien in cerebrospinal fluid was significantly higher than that of serum(P<0.01).The release of C-reactive protien in serum and cerebrospinal fluid in patients with acute cerebral infarction was associated with the neurological outcome at discharge from hospital as assessed by Chinese stroke scale scores(P<0.01).Conclusion:Our results show that the concentration of C- reactive protien in serum and cerebrospinal fluid in patients with acute cerebral infarction indicates the severity of the disease or the extent of neural lesion.It is a useful biochemical marker for brain-tissue damage. Measurement of C- reactive protien concentration in serum and cerebrospinal fluid in patients may be used to explore the ischemic mechanism with acute cerebral infarction

and it may also be used as a valuable tool and progrostic parameter for estimating lesion range and clinical stroke treatment.

关键词

C-反应蛋白急性脑梗死神经功能康复

Keywords

C-reactive proteinacute cerebral infarctionNeurologic functional rehabilitation

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