Expression and significance of P27 in hepatocellular carcinomas

ZHANG Wei; et al

doi:10.13406/j.cnki.cyxb.2004.04.017

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Expression and significance of P27 in hepatocellular carcinomas

更新时间：2024-01-17

- Expression and significance of P27 in hepatocellular carcinomas
- Journal of Chongqing Medical University Issue 4, Pages: 465-467(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院普外科
  2. 重庆医科大学临床学院普外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.04.017
  CLC： R735.7
- Published：2004，
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[1]张伟,杜成友,徐尔侃.肝癌中P27的表达及其意义[J].重庆医科大学学报,2004(04):465-467.

ZHANG Wei, et al. Expression and significance of P27 in hepatocellular carcinomas. [J]. Journal of Chongqing Medical University (4):465-467(2004)
[1]张伟,杜成友,徐尔侃.肝癌中P27的表达及其意义[J].重庆医科大学学报,2004(04):465-467. DOI： 10.13406/j.cnki.cyxb.2004.04.017.

ZHANG Wei, et al. Expression and significance of P27 in hepatocellular carcinomas. [J]. Journal of Chongqing Medical University (4):465-467(2004) DOI： 10.13406/j.cnki.cyxb.2004.04.017.

摘要

目的 :研究P2 7蛋白在肝细胞癌中的表达和意义。方法 :选取经手术治疗的肝癌患者标本 5 0例

癌旁组织 2 2例

正常肝组织 9例

用免疫组化方法检测这些组织中P2 7表达指数（P2 7LI）。结果 :肝癌组织中P2 7LI比癌旁组织高（P =0 .0 0 2 ）

而癌旁组织比正常对照肝组织高（P =0 .0 0 7）。P2 7蛋白的表达与肿瘤的分化、分期、肿瘤直径大小以及有无门静脉侵犯和有无肝内转移相关。P2 7LI≥ 5 0 %的肝癌患者术后生成时间明显延长（P =0 .0 0 4 ）。结论 :P2 7在早期肝癌中有阻止癌细胞增殖的作用

其在肝癌组织中的表达有助于判断肿瘤的进展程度

是一个有用的预后指标

Abstract

Objective:To study the expression and its significance of P27 protein in hcpatocellular carcinomas(HCC).Methods:Expression of P27 protein is investigated by immunohistochemistry technique(SP) in 50 cases of hepatocellular carcinoma who had undergone surgery for HCC

22 cases of their adjacent noncancerous lesions and 9 cases normal liver control specimens.Results:The P27 LI in hepatocellular carcinomas was higher than that in the adjacent noncancerous lesions (P=0.002).Furthermore

the P27LI in adjacent noncancerous lesions was significantly highter than that in normal liver lesions (P=0.007).The expression of P27 was significantly correlated with tumor differentiation

stage

size

portal invasion

and intrahepatic metastasis.The post-operation survival time for patients with P27LI≥50% was longer than those with P27 LI<50%’s (P=0.004).Conclusion:These findings suggest that in HCC P27 is active against HCC progression in early phases and may be helpful in determining tumor progression.And it may serve as an available prognostic marker.

关键词

肝细胞癌P27蛋白免疫组织化学

Keywords

Hepatocellular carcinomasP27 proteinimmunohistochemistry

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重庆医科大学基础医学院病理教研室

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