The insulin resistance after traumatic brain injury in rats

HE Zhaohui; et al

doi:10.13406/j.cnki.cyxb.2004.04.016

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The insulin resistance after traumatic brain injury in rats

更新时间：2024-01-17

- The insulin resistance after traumatic brain injury in rats
- Journal of Chongqing Medical University Issue 4, Pages: 462-464(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院神经外科
  2. 重庆医科大学临床学院神经外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.04.016
  CLC： R651.1
- Published：2004，
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[1]何朝晖,支兴刚,唐文渊,石全红.大鼠创伤性脑损伤后胰岛素抵抗的研究[J].重庆医科大学学报,2004(04):462-464+470.

HE Zhaohui, et al. The insulin resistance after traumatic brain injury in rats. [J]. Journal of Chongqing Medical University (4):462-464(2004)
[1]何朝晖,支兴刚,唐文渊,石全红.大鼠创伤性脑损伤后胰岛素抵抗的研究[J].重庆医科大学学报,2004(04):462-464+470. DOI： 10.13406/j.cnki.cyxb.2004.04.016.

HE Zhaohui, et al. The insulin resistance after traumatic brain injury in rats. [J]. Journal of Chongqing Medical University (4):462-464(2004) DOI： 10.13406/j.cnki.cyxb.2004.04.016.

摘要

目的 :探讨大鼠创伤性脑损伤后是否存在胰岛素抵抗现象。方法 :采用大鼠自由落体脑损伤模型（Feeney’smodel）

分别在伤前 1/2h及伤后 6、12、2 4、4 8、72、12 0h测定轻、中、重型脑损伤动物的血糖和血清胰岛素值。运用正常血糖 -高血胰岛素钳夹技术

检测大鼠重型创伤性脑损伤后 2 4h后BG60 -12 0 、GIR60 -12 0 、ISI等 3个反映胰岛素敏感性的指标。结果 :中、重型创伤性脑损伤后大鼠血糖含量升高的同时血清胰岛素水平升高

大鼠重型创伤性脑损伤后 2 4hBG60 -12 0 显著地升高

GIR60 -12 0 、ISI显著地降低。结论 :在重型创伤性脑损伤急性期

大鼠血糖和血清胰岛素水平均显著地升高

高水平的胰岛素未能起到相应的降低血糖的作用

与机体产生胰岛素抵抗有关

Abstract

Objective:To study the insulin resistance after traumatic brain injury in rats.Methods:Based upon the Feeney’s model

the blood glucose and insulin concentration of each animal group were measured 1/2 hour before injury and 6

120 hours after injury;the three indices BG

60-120

GIR

60-120

ISI reflecting the insulin sensitivity were measured 24 hours after severe traumatic brain injury by euglycemic-hyperinsulinemic clamp technique.Results:Both the blood glucose and insulin concentration increased markedly in medium and severely injured group after injury.BG

60-120

increased markedly and GIR

60-120

ISI decreased significantly 24 hours after severe trauma in injured animal compared with sham group.Conclusion:Both the blood glucose and insulin concentration increase markedly in severe injured group after injury.The fact that higher-level insulin cannot reduce the increased blood glucose is due to acute insulin resistance developing after traumatic brain injury.

关键词

创伤性脑损伤胰岛素抵抗正常血糖-高血胰岛素钳夹技术

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