The effects of TP and EGCG on the adherence and invasion of MDA-MB-231 human breast cancer cells

LU Li; et al

doi:10.13406/j.cnki.cyxb.2004.04.010

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The effects of TP and EGCG on the adherence and invasion of MDA-MB-231 human breast cancer cells

更新时间：2024-01-17

- The effects of TP and EGCG on the adherence and invasion of MDA-MB-231 human breast cancer cells
- Journal of Chongqing Medical University Issue 4, Pages: 441-443(2004)
- 作者机构：
  
  1. 重庆医科大学基础医学院病理生理教研室
  2. 重庆医科大学基础医学院病理生理教研室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.04.010
  CLC： R737.9
- Published：2004，
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[1]鲁藜,邓华瑜.茶多酚与EGCG对人乳癌细胞株侵袭影响的研究[J].重庆医科大学学报,2004(04):441-443.

LU Li, et al. The effects of TP and EGCG on the adherence and invasion of MDA-MB-231 human breast cancer cells. [J]. Journal of Chongqing Medical University (4):441-443(2004)
[1]鲁藜,邓华瑜.茶多酚与EGCG对人乳癌细胞株侵袭影响的研究[J].重庆医科大学学报,2004(04):441-443. DOI： 10.13406/j.cnki.cyxb.2004.04.010.

LU Li, et al. The effects of TP and EGCG on the adherence and invasion of MDA-MB-231 human breast cancer cells. [J]. Journal of Chongqing Medical University (4):441-443(2004) DOI： 10.13406/j.cnki.cyxb.2004.04.010.

摘要

目的 :观察茶多酚和EGCG[（- ） -epigallocatechin - 3- gallate表没食子儿茶素没食子酸酯 ]对人乳腺癌细胞株MDA -MB - 2 31粘附和侵袭运动能力的影响。方法 :用 12 5 μg/ml茶多酚、EGCG处理后人乳腺癌MDA -MB - 2 31高转移细胞株

分别用MTT法、Transwell侵袭运动实验来研究茶多酚、EGCG对细胞的粘附和侵袭运动能力的影响。结果 :经茶多酚、EGCG处理后

MDA -MB - 2 31对细胞外基质成分的粘附能力降低

同时侵袭能力降低。结论 :茶多酚和EGCG可能通过抑制肿瘤细胞的粘附和侵袭运动能力来发押预防肿瘤侵袭的作用

茶多酚的抗粘附侵袭能力表现较EGCG显著

Abstract

Objective:To investigate the effects of EGCG on the in vitro adhesion

invasion and motility of MDA-MB-231 cells

and explore the possible mechanism of the preventive effects of EGCG on tumor metastasis.Methods:MDA-MB-231 cells were cultured in RPMI-1640 medium

10% fetal bovine serum and 0(control)

125μg/ml TP

EGCG for 48 hours in vitro

the adhesion and invasion ability of EGCG-treated cells was investigated with MTT colorimetric assay and transwell.Results:The ability of EGCG-treated cells to adhere to Matrigel decreased significantly(P<0.01)

EGCG inhibited the invasion of MDA-MB-231.Conclusion:TP and EGCG may prevent metastasis by affecting adhesion

invasion and migration ability of tumor cells.

关键词

茶多酚EGCG（表没食子儿茶素没食子酸酯）人乳腺癌细胞株MDA-MB-231粘附肿瘤侵袭MTT

Keywords

TPEGCGMDA-MB-231AdhesionInvasionMTT

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