Experimental study on hydroxychloroquine raised insulin sensitivity in insulin resistance rat models

WANG Zhihong; et al

doi:10.13406/j.cnki.cyxb.2004.04.007

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Experimental study on hydroxychloroquine raised insulin sensitivity in insulin resistance rat models

更新时间：2024-01-17

- Experimental study on hydroxychloroquine raised insulin sensitivity in insulin resistance rat models
- Journal of Chongqing Medical University Issue 4, Pages: 429-432(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院内分泌科
  2. 第三军医大学大坪医院高血压内分泌科
  3. 北京大学人民医院内分泌科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.04.007
  CLC： R587.6
- Published：2004，
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[1]汪志红,张素华,倪银星,吴静,王继旺,龚俐琳.羟氯喹增加胰岛素抵抗大鼠模型胰岛素敏感性的实验研究[J].重庆医科大学学报,2004(04):429-432.

WANG Zhihong, et al. Experimental study on hydroxychloroquine raised insulin sensitivity in insulin resistance rat models. [J]. Journal of Chongqing Medical University (4):429-432(2004)
[1]汪志红,张素华,倪银星,吴静,王继旺,龚俐琳.羟氯喹增加胰岛素抵抗大鼠模型胰岛素敏感性的实验研究[J].重庆医科大学学报,2004(04):429-432. DOI： 10.13406/j.cnki.cyxb.2004.04.007.

WANG Zhihong, et al. Experimental study on hydroxychloroquine raised insulin sensitivity in insulin resistance rat models. [J]. Journal of Chongqing Medical University (4):429-432(2004) DOI： 10.13406/j.cnki.cyxb.2004.04.007.

摘要

目的 :观察羟氯喹对高脂饮食大鼠胰岛素敏感性的影响。方法 :高脂大鼠灌服羟氯喹后用正常葡萄糖钳夹试验测定胰岛素敏感性（GIR6 0 - 12 0 ）

并测量血糖、血脂和胰岛素等。结果 :（1）高脂喂养 4周

大鼠的空腹血糖、胰岛素、血脂、体重均显著增高

胰岛素敏感性下降。（2 ）服用羟氯喹、罗格列酮和二甲双胍 2周后

高脂大鼠的胰岛素敏感性显著改善

GIR6 0 -12 0值分别为 9.3± 1.2、11.6± 1.4、9.8± 1.3、mg·kg - 1min - 1

服用羟氯喹大鼠的血糖、血脂显著低于服安慰剂的高脂大鼠。结论 :（1）高脂喂养法成功地制备了胰岛素抵抗大鼠模型。（2 ）羟氯喹能增加胰岛素敏感性

其作用与二甲双胍相似

但不及罗格列酮 ;羟氯喹对血糖、血脂也有一定的改善作用

Abstract

Objective:To observe the effects of hydroxychloroquine on insulin sensitivity in high-fat feeding rats.Methods:After administrating hydroxychloroquine

the glucose infusion rate (GIR) determined by euglycemic clamp was used to measure the insulin sensitivity

and determining fasting plasma glucose

lipid and insulin.Results:(1)In high-fat feeding rats

the GIR60-120 was lower and the fasting plasma glucose

insulin

lipid levels were higher than those in normal feeding rats.(2)Hydroxychloroquine

rosiglitazone and metformin increased insulin sensitivity (the value of GIR60-120 was 9.3±1.2

11.6±1.4 and 9.8±1.3 mg.kg/min

respectively) in insulin resistance (IR) models.Moreover

the fasting glucose and some plasma lipid indices were improved in the IR rats with hydroxychloroquine administration.Conclusion:It is indicated that hydroxychloroquine could raise insulin sensitivity of IR rats with high-fat feeding

which was similar to metfomin but lower than rosiglitazone.In addition

hydroxychloroquine also could improve the glucose and blood lipid of the IR rats in some extent.

关键词

羟氯喹罗格列酮二甲双胍胰岛素敏感性胰岛素抵抗

Keywords

hydroxychloroquinerosiglitazonemetformininsulin sensitivityinsulin resistance

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