Exploration of clinical diagnostic value of measuring sulfate glycosaminoglycan segment and antibody to tuberculosis in patients with hydrothorax

LI Minchao; et al

doi:10.13406/j.cnki.cyxb.2004.03.046

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Exploration of clinical diagnostic value of measuring sulfate glycosaminoglycan segment and antibody to tuberculosis in patients with hydrothorax

更新时间：2024-01-17

- Exploration of clinical diagnostic value of measuring sulfate glycosaminoglycan segment and antibody to tuberculosis in patients with hydrothorax
- Journal of Chongqing Medical University Issue 3, Pages: 389-391(2004)
- 作者机构：
  
  1. 重庆医科大学第二临床学院呼吸内科
  2. 重庆医科大学第二临床学院呼吸内科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.03.046
  CLC： R446.6
- Published：2004，
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[1]李敏超,张和生,陈小铃,陈景玉.硫酸氨基葡糖多聚糖片段与结核抗体检测对胸腔积液诊断价值的探讨[J].重庆医科大学学报,2004(03):389-391.

LI Minchao, et al. Exploration of clinical diagnostic value of measuring sulfate glycosaminoglycan segment and antibody to tuberculosis in patients with hydrothorax. [J]. Journal of Chongqing Medical University (3):389-391(2004)
[1]李敏超,张和生,陈小铃,陈景玉.硫酸氨基葡糖多聚糖片段与结核抗体检测对胸腔积液诊断价值的探讨[J].重庆医科大学学报,2004(03):389-391. DOI： 10.13406/j.cnki.cyxb.2004.03.046.

LI Minchao, et al. Exploration of clinical diagnostic value of measuring sulfate glycosaminoglycan segment and antibody to tuberculosis in patients with hydrothorax. [J]. Journal of Chongqing Medical University (3):389-391(2004) DOI： 10.13406/j.cnki.cyxb.2004.03.046.

摘要

目的 :探讨硫酸氨基葡糖多聚糖（GAG）片段及结核分枝杆菌IgG抗体（TB -IgG）检测对结核性胸水、恶性胸水的诊断价值。方法 :应用肺肿瘤抗原（LTA）诊断试剂盒和结核分枝杆菌抗体胶体金诊断试剂盒

分别定性测定 35 7例胸水患者血清、胸水中的GAG片断和TB -IgG

并进行回顾性调查分析

统计试验资料。结果 :癌性患者胸水GAG检测的阳性率、特异性分别为 80 .3% （ 10 6 / 132 ）、88.4 % ;血清GAG检测的阳性率、特异性分别为 5 4 .5 % （ 72 / 132 ）和 90 .2 %。结核性患者胸水TB-IgG检测的阳性率、特异性分别为 6 6 .2 % （ 10 2 / 15 4 ）和 86 .2 % ;血清为 33.8% （ 5 2 / 15 4 ）和 83.7%。胸水GAG联合TB -IgG的检测来诊断结核性胸膜炎和恶性胸膜炎

则可使两者的诊断特异性增加到 97.0 %和 98.2 %。结论 :胸水GAG及TB -IgG的检测对结核性胸膜炎和恶性胸膜炎有一定诊断价值

胸水GAG和TB -IgG的联合检测因特异性高

可作为结核性胸水和癌性胸水的鉴别诊断指标。

Abstract

Objective:To explore the clinical value of detection of sulfated glycosaminoglycan(GAG) segment and IgG antibody to tuberculosis(TB-IgG) to diagnose tuberculous pleuritis and malignant pleural effusion.Methods:Using the lung tumor antigen(LTA) diagnostic kit and tuberculosis antibody colloidal gold diagnostic kit to detecte the GAG and TB-IgG of serum and pleural fluid separately of 357 patients suffering from hydrothorax.We proceeded a retrospective study and then had statistical evidence.Results:The positive rate and specificity of GAG of pleural effusion of lung cancer patients were 80.3%(106/132)

88.4%

and that of serum were 54.5%(72/132)

90.2%.The positive rate and specificity of TB-IgG of pleural effusion of tuberculous pleuritis were 66.2%(102/154)

86.2%

and that of serum were 33.8%(52/154)

83.7%.The specificity of GAG

combined with TB-IgG by measuring the pleural fluid of tuberculous pleuritis and malignant pleural effusion would increase to 97.0% and 98.2% separately.Conclusion:Detection of GAG and TB-IgG of pleural fluid is helpul for diagnosis of tuberculous pleuritis and malignant pleural effusion.GAG combined with TB-IgG can act as differential diagnosis marker of tuberculous pleuritis and malignant pleural effusion for its higher specificity.

关键词

硫酸氨基葡糖多聚糖结核分枝杆菌抗体结核性胸膜炎恶性胸水

Keywords

Sulfate glycosaminoglycan segmentAntibody to tuberculosisTuberculous pleuritisMalignant pleural effusion

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