Relationship between idiopathic thrombocytopenic purpura and virus infection in children

XIAN Ying; et al

doi:10.13406/j.cnki.cyxb.2004.03.040

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Relationship between idiopathic thrombocytopenic purpura and virus infection in children

更新时间：2024-01-17

- Relationship between idiopathic thrombocytopenic purpura and virus infection in children
- Journal of Chongqing Medical University Issue 3, Pages: 375-376(2004)
- 作者机构：
  
  1. 重庆医科大学儿科学院血液科
  2. 重庆医科大学儿科学院肿瘤科,重庆,400014
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.03.040
  CLC： R725.5
- Published：2004，
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[1]宪莹,徐酉华.小儿特发性血小板减少性紫癜与病毒感染的关系[J].重庆医科大学学报,2004(03):375-376.

XIAN Ying, et al. Relationship between idiopathic thrombocytopenic purpura and virus infection in children. [J]. Journal of Chongqing Medical University (3):375-376(2004)
[1]宪莹,徐酉华.小儿特发性血小板减少性紫癜与病毒感染的关系[J].重庆医科大学学报,2004(03):375-376. DOI： 10.13406/j.cnki.cyxb.2004.03.040.

XIAN Ying, et al. Relationship between idiopathic thrombocytopenic purpura and virus infection in children. [J]. Journal of Chongqing Medical University (3):375-376(2004) DOI： 10.13406/j.cnki.cyxb.2004.03.040.

摘要

目的 :探讨小儿特发性血小板减少性紫癜（ITP）与多种病毒感染的关系。方法 :用ELISA技术对 10 2例诊断明确的ITP患儿进行人细小病毒（HPVB19）

柯萨基病毒（CBV1- 6 ）

人类巨细胞病毒（HCMV）及EB病毒（EBV）特异性IgM的检测。结果 :10 2例ITP中HPVB19-IgM阳性 4 1例（ 4 0 .12 % ） ;CBV1- 6 -IgM阳性 2 8例（ 2 7.4 5 % ） ;HCMV -IgM阳性 17例（ 16 .6 6 % ） ;EBV -IgM阳性 7例（ 6 .86 % ） ;四种病毒总阳性率 5 0 .98%

除EBV外其他三种病毒感染阳性率均明显高于正常对照组

两组比较有显著性差异（P <0 .0 5 ）。结论 :（ 1）病毒感染是小儿ITP的主要致病因素 ;（ 2 ）HPVB19感染是引起ITP最常见的病因 ;（ 3）HCMV感染与婴儿ITP的发生、治疗效果及预后有着明确的关系 ;（ 4 ）CBV1- 6感染也是ITP的主要致病因素之一。

Abstract

Objective:To study the relationship between idiopathic thrombocytopenic purpura (ITP) and various virus infections in children.Methods:The human parvovirusB 19(HPV-B 19)

Epstein-Barr virus(EBV)

Cytomegalovirus and Coxsackie virus (CBV 1-6) were detected using ELISA test in 102 patients with ITP.Results:The HPVB-19 IgM was positive in 41 patients(40.12%).CBV1-6 IgM was positive in 28 patients(27.45%).The CMV IgM was positive in 17 patients(16.66%).The EBV IgM was positive in 7 patients(6.86% ).The total rate of these four viruses was 50.98% of the patients with ITP observed in this study.Except EBV

the virus infections positive rate in this study were significantly higher than that of control group.( P <0.05).Conclusion:(1)These results suggest that the pathogenesis of ITP in childhood might be correlated with virus infections.(2)HPV-B19 infecteion is the most common virus in the patients with ITP.(3)The CMV infection is associated with the treatment effect and prognosis clinically in infant with ITP.(4)The CBV1-6 infection may be one of the virus caused ITP.

关键词

特发性血小板减少性紫癜病毒感染儿童

Keywords

Idiopathic thrombocytopenic purpura (ITP)Virus infectionchildren

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