An experimental study on the expression of TNF-α in myocardial injury during stress

DENG Shixiong; et al

doi:10.13406/j.cnki.cyxb.2004.03.019

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An experimental study on the expression of TNF-α in myocardial injury during stress

更新时间：2024-01-17

- An experimental study on the expression of TNF-α in myocardial injury during stress
- Journal of Chongqing Medical University Issue 3, Pages: 315-317(2004)
- 作者机构：
  
  1. 重庆医科大学基础医学院法医学教研室
  2. 四川省遂宁市人民医院普外科,重庆,400016
  3. ,遂宁,629000
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.03.019
  CLC： R542.22
- Published：2004，
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[1]邓世雄,田田.TNF-α在小鼠心肌应激性损伤中表达的实验研究[J].重庆医科大学学报,2004(03):315-317.

DENG Shixiong, et al. An experimental study on the expression of TNF-α in myocardial injury during stress. [J]. Journal of Chongqing Medical University (3):315-317(2004)
[1]邓世雄,田田.TNF-α在小鼠心肌应激性损伤中表达的实验研究[J].重庆医科大学学报,2004(03):315-317. DOI： 10.13406/j.cnki.cyxb.2004.03.019.

DENG Shixiong, et al. An experimental study on the expression of TNF-α in myocardial injury during stress. [J]. Journal of Chongqing Medical University (3):315-317(2004) DOI： 10.13406/j.cnki.cyxb.2004.03.019.

摘要

目的 :探讨TNF -α在应激性心肌损伤中的表达和意义。方法 :以异丙肾上腺素（isoproterenol

ISO）作腹腔注射

建立小鼠应激性心肌损伤模型

应用免疫组化SP方法检测TNF -α在小鼠心肌中的表达。结果 :TNF -α在正常对照组偶见于局部视野的心肌细胞及血管内皮细胞（VEC） ;TNF -α在应激组的表达大大增加

且增加的程度与心肌的损害程度一致。结论 :TNF -α在应激性心肌损伤中的表达明显增加

其增加程度与心肌损伤的程度密切相关

提示TNF -α在这种心肌损伤的病理过程中起重要作用

Abstract

Objective:To detect TNF-α in the tissue of myocardium injury during stress and discuss its significance.Methods:To establish a model of myocardium lesion by injecting ISO to mice abdominal cavity

then TNF-α in the tissue of heart was assessed by immunohistochemical method of SP and HE staining in paraffin sections.Results:There were little positive substance of TNF-α expressed in heart in normal control.The positive substance of TNF-α increased significantly after stress.Conclusion:Increase in the expression of TNF-α in stress indicate its participation in the process of myocardium injury

and it may be an objective marker for evaluation of myocardium injury.

关键词

TNF-α异丙肾上腺素心肌损伤免疫组织化学

Keywords

TNF-αISOMyocardium injuryImmunohistochemical method

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