The preventive effect of fastigial nucleus stimulation on the oxidative damage in rats with myocardial infarction

ZHANG Runfeng; CHEN Yunzhen

doi:10.13406/j.cnki.cyxb.2004.03.018

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The preventive effect of fastigial nucleus stimulation on the oxidative damage in rats with myocardial infarction

更新时间：2024-01-17

- The preventive effect of fastigial nucleus stimulation on the oxidative damage in rats with myocardial infarction
- Journal of Chongqing Medical University Issue 3, Pages: 311-314(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院心内科
  2. 重庆医科大学临床学院心内科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.03.018
  CLC： R542.2
- Published：2004，
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[1]张润峰,陈运贞.电刺激小脑顶核防治心肌梗死后大鼠心肌氧化损伤[J].重庆医科大学学报,2004(03):311-314.

ZHANG Runfeng, CHEN Yunzhen. The preventive effect of fastigial nucleus stimulation on the oxidative damage in rats with myocardial infarction. [J]. Journal of Chongqing Medical University (3):311-314(2004)
[1]张润峰,陈运贞.电刺激小脑顶核防治心肌梗死后大鼠心肌氧化损伤[J].重庆医科大学学报,2004(03):311-314. DOI： 10.13406/j.cnki.cyxb.2004.03.018.

ZHANG Runfeng, CHEN Yunzhen. The preventive effect of fastigial nucleus stimulation on the oxidative damage in rats with myocardial infarction. [J]. Journal of Chongqing Medical University (3):311-314(2004) DOI： 10.13406/j.cnki.cyxb.2004.03.018.

摘要

目的 :研究电刺激小脑顶核（FNS）对急性心肌梗死（AMI）大鼠心肌氧化损伤的防治作用机制。方法 :随机将大鼠分为AMI、FNS +AMI、毁损小脑顶核（FNL） +AMI组

于左冠状动脉结扎术后 2 4h进行心肌梗死面积、血清乳酸脱氢酶（LDH）和肌酸激酶（CK）活性、心肌组织丙二醛（MDA）含量和总抗氧化能力（TAOC）及超氧化物歧化酶（SOD）活性测定。结果 :与MI组比较

FNS +AMI组LDH、CK活性

MDA含量

心肌梗死面积显著减少（P <0 .0 1） ;TAOC及SOD活性显著升高（P <0 .0 1）。FNL +AMI组与AMI组以上指标比较无显著性差异（P >0 .0 5 ）。结论 :FNS可减轻心肌梗死后大鼠心肌损伤

减小心肌梗死面积 ;其心肌保护机制可能与其抗氧化损伤作用有关。

Abstract

Objective:To investigate the effect of fastigial nucleus stimulation(FNS) on preventing oxidative damage from myocardium after acute myocardial infarction in rats.Methods:Wistar rats were randomly divided into acute myocardial infarction(AMI)

FNS before AMI model was made(FNS+AMI)

bilateral fastigial nucleus lesion(FNL) before AMI(FNL+AMI) groups.At 24 hours after coronary ligation

blood samples and left ventricular myocardium were obtained for measurment of the activity of lactic dehydrogenase(LDH) and creatine phosphokinase(CK) in serum

as well as myocardial infarct size.At the same time

the malondialdehyde(MDA) level

total anti-oxidative capability (TAOC) and superoxide dismutase(SOD) activity in myocardium were measured too.Results:LDH

CK activities and MDA level in FNS+AMI group were significantly lower than that in AMI group( P <0.01).The infarct size in FNS+AMI group was significantly smaller than that in group AMI( P <0.01).SOD activity and TAOC were significantly increased in FNS+AMI group as compared to AMI group.There was no significant difference between FNL+AMI group and AMI group for all the measurements( P >0.05).Conclusion:FNS can attenuate the damage of myocardium from infarct heart and reduce myocardial infarct size.The mechanism of the protective effect coming from FNS may be related to its antioxidative role.

关键词

小脑顶核电刺激心肌梗死抗氧化

Keywords

Fastigial nucleuselectrical stimulationMyocardical infarctionAntioxidant

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