Effect of liposome-c-raf-1 antisense oligodeoxynucleotides on human ovarian carcinoma transplanted subcutaneously in nude mice

WU Yongzhong; et al

doi:10.13406/j.cnki.cyxb.2004.03.015

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Effect of liposome-c-raf-1 antisense oligodeoxynucleotides on human ovarian carcinoma transplanted subcutaneously in nude mice

更新时间：2024-01-17

- Effect of liposome-c-raf-1 antisense oligodeoxynucleotides on human ovarian carcinoma transplanted subcutaneously in nude mice
- Journal of Chongqing Medical University Issue 3, Pages: 302-304(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院肿瘤科
  2. 重庆医科大学核医学教研室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.03.015
  CLC： R737.31
- Published：2004，
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[1]吴永忠,任庆兰,李少林.脂质体-c-raf-1反义寡核苷酸治疗人卵巢癌裸鼠皮下移植瘤[J].重庆医科大学学报,2004(03):302-304.

WU Yongzhong, et al. Effect of liposome-c-raf-1 antisense oligodeoxynucleotides on human ovarian carcinoma transplanted subcutaneously in nude mice. [J]. Journal of Chongqing Medical University (3):302-304(2004)
[1]吴永忠,任庆兰,李少林.脂质体-c-raf-1反义寡核苷酸治疗人卵巢癌裸鼠皮下移植瘤[J].重庆医科大学学报,2004(03):302-304. DOI： 10.13406/j.cnki.cyxb.2004.03.015.

WU Yongzhong, et al. Effect of liposome-c-raf-1 antisense oligodeoxynucleotides on human ovarian carcinoma transplanted subcutaneously in nude mice. [J]. Journal of Chongqing Medical University (3):302-304(2004) DOI： 10.13406/j.cnki.cyxb.2004.03.015.

摘要

目的 :探讨c-raf- 1反义寡脱氧核苷酸（ASODN）对人卵巢癌裸鼠皮下移植瘤的治疗作用。方法 :将 15只裸鼠建立人卵巢癌裸鼠皮下移植瘤模型

然后随机分成 3组予以不同条件处理 :对照组（腹腔注射转染液和脂质体）

正义治疗组（腹腔注射脂质体 -c -raf- 1-SODN）

反义治疗组（腹腔注射脂质体 -c -raf- 1-ASODN）。治疗期间定期观测裸鼠体重并测量肿瘤体积

计算抑瘤率及肿瘤缩小率。结果 :反义治疗组与正义治疗组的抑瘤率分别为 6 8.1%和 6 .8%

反义治疗组肿瘤缩小率为 16 .7%

与正义治疗组相比较有明显的差别。各组裸鼠体重变化无明显差别。结论 :脂质体 -c -raf - 1-ASODN对人卵巢癌裸鼠皮下移植瘤有一定的治疗价值

可能成为日后基因治疗的重要方向

Abstract

Objective:To explore the effect of c-raf-1 antisense oligodeoxynucleotides (ASODN) treatment in the human ovarian epithelial cancer transplanted subcutaneously in nude mice.Methods:The models of human ovarian epithelial cancer transplanted subcutaneously were established in 15 nude mice

then divided randomly into 3 groups and different treatment were given respectively (control group

senseexperimental group and antisense experimental group).The weight of nude mice and tumor volume were observed

the tumor growth inhibitory rate and the tumor response rate calculated

too.Results:The growth inhibitory rate in sense experimental group and antisense experimental group were 6.8% and 68.1%

respectively

the tumor response rate of antisense experimental group was 16.7%.There was no statistical difference in nude mice weight among the 3 groups.Conclusion:The results suggest that there is a positive value in the human ovarian epithelial cancer transplanted subcutaneously in nude mice treated by c-raf-1 antisense oligodeoxynucleotides

which will be an important gene therapeutic strategy for the ovarian epithelial carcinoma in the future.

关键词

反义寡脱氧核苷酸c-raf-1基因人卵巢上皮癌裸鼠皮下移植瘤

Keywords

Antisense oligodeoxynucleotidesc-raf-1geneOvarian epithelial carcinomaTumor transplanted subcutaneously in nude mice

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