Effects of house dust mite injected in neonate rats on airway inflammation and TH subset in later life

DAI Jihong; et al

doi:10.13406/j.cnki.cyxb.2004.03.014

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Effects of house dust mite injected in neonate rats on airway inflammation and TH subset in later life

更新时间：2024-01-17

- Effects of house dust mite injected in neonate rats on airway inflammation and TH subset in later life
- Journal of Chongqing Medical University Issue 3, Pages: 299-301(2004)
- 作者机构：
  
  1. 重庆医科大学儿科学院呼吸科
  2. 重庆医科大学临床学院药剂科,重庆,400014
  3. ,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.03.014
  CLC： R725.6
- Published：2004，
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[1]代继宏,符州,刘宇.新生大鼠注射尘螨对其发育后期气道炎症作用的研究[J].重庆医科大学学报,2004(03):299-301.

DAI Jihong, et al. Effects of house dust mite injected in neonate rats on airway inflammation and TH subset in later life. [J]. Journal of Chongqing Medical University (3):299-301(2004)
[1]代继宏,符州,刘宇.新生大鼠注射尘螨对其发育后期气道炎症作用的研究[J].重庆医科大学学报,2004(03):299-301. DOI： 10.13406/j.cnki.cyxb.2004.03.014.

DAI Jihong, et al. Effects of house dust mite injected in neonate rats on airway inflammation and TH subset in later life. [J]. Journal of Chongqing Medical University (3):299-301(2004) DOI： 10.13406/j.cnki.cyxb.2004.03.014.

摘要

目的 :研究早期接触屋尘螨（HDM）能否加重后期哮喘发作时的气道炎症及其相关免疫学机理。方法 :新生Wistar大鼠生后即注射HDM提取液

制作哮喘模型

检测血IL - 4及IFN -γ水平、OVA -IgE水平、支气管肺泡灌洗液（BALF）中嗜酸性粒细胞（EOS）计数。结果 :HDM组EOS百分比、血清OVA特异性IgE水平、IL - 4水平分别为（ 37.0 7± 1.10 ） %、（ 0 .2 0 4± 0 .0 2 3）和（ 78.96± 12 .18） pg/ml

为最高

而IFN -γ水平最低

为（ 93.78± 2 .10 ） pg/ml。结论 :生后早期接触HDM能加重以后气道变态反应性炎症

与TH1/TH2失衡有关

Abstract

Objective:To study whether early exposure to house dust mite will aggravate airway inflammation as well as the onset of asthma and to explore the relevant mechanism.Methods:Neonate Wistar rats were injected with HDM subcutaneously instantly after birth.After the four times management

they were established as models of asthma with OVA

and bronchoalveolus was lavaged to count percentage of eosinophils.And levels of IL-4

IFN-γ and serum OVA-IgE were also detected.Results:In HDM group

the percentage of EOS

level of serum OVA-IgE and level of IL-4 were (37.07±1.10) %

(0.20±0.023) and (78.96±12.18) pg/ml

respectively

the highest among the three groups

otherwise level of IFN-γ

the lowest

(93.78±2.10)pg/ml.Conclusion:Early exposure to house dust mite after birth could aggravate the level of airway inflammation in later life and increase the level of IgE

which is related with T H1/T H2 imbalance.

关键词

哮喘动物模型TH亚群螨

Keywords

asthmaanimal modelTH subsetMite

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Related Institution

Laboratory for Clinical Immunology,the Children’s Hospital,Chongqing Medical University

重庆医科大学公共卫生学院统计教研室

重庆医科大学附属儿童医院免疫室

Department of Traditional Chinese Medicine，Children’s Hospital，Zhejiang University School of Medicine/ National Clinical Research Center for Child Health

Department of Pediatrics，The Affiliated Hospital of Nanjing University of Chinese Medicine，The First Clinical Medical College of Nanjing University of Chinese Medicine

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