The study of Lonicera extract from water solution on ovalbumin-induced allergic mice model

LI Fei; et al

doi:10.13406/j.cnki.cyxb.2004.03.011

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The study of Lonicera extract from water solution on ovalbumin-induced allergic mice model

更新时间：2024-01-17

- The study of Lonicera extract from water solution on ovalbumin-induced allergic mice model
- Journal of Chongqing Medical University Issue 3, Pages: 288-291(2004)
- 作者机构：
  
  1. 重庆医科大学儿科学院儿童保健科
  2. 重庆医科大学儿科学院儿童保健科,重庆,400014
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.03.011
  CLC： R285
- Published：2004，
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[1]李斐,黎海芪.金银花水提物对卵清蛋白致敏小鼠的抗过敏作用研究[J].重庆医科大学学报,2004(03):288-291.

LI Fei, et al. The study of Lonicera extract from water solution on ovalbumin-induced allergic mice model. [J]. Journal of Chongqing Medical University (3):288-291(2004)
[1]李斐,黎海芪.金银花水提物对卵清蛋白致敏小鼠的抗过敏作用研究[J].重庆医科大学学报,2004(03):288-291. DOI： 10.13406/j.cnki.cyxb.2004.03.011.

LI Fei, et al. The study of Lonicera extract from water solution on ovalbumin-induced allergic mice model. [J]. Journal of Chongqing Medical University (3):288-291(2004) DOI： 10.13406/j.cnki.cyxb.2004.03.011.

摘要

目的 :观察金银花水提物对卵清蛋白致敏小鼠Ⅰ型变态反应的影响

为临床用于治疗儿童食物过敏症提供药理学依据。方法 :观察金银花对卵清蛋白介导的热不稳定性及热稳定性小鼠被动皮肤过敏反应（PCA）的影响

及对致敏小鼠小肠HE染色

甲苯胺兰染色

小肠组织胺含量的影响。结果 :高、中浓度组金银花水提物连续灌胃给药 10天

可抑制卵清蛋白介导的小鼠同种热不稳定性PCA反应（P <0 .0 1）

不抑制热稳定性同种PCA反应（P >0 .0 5 ）。同时缓解过敏小鼠小肠炎症及肥大细胞聚集和脱颗粒现象

提高小肠固有层完整肥大细胞的百分率（P <0 .0 1）

使过敏小鼠小肠组织胺的含量升高（P <0 .0 1）

且高浓度组高于中浓度组（P <0 .0 1）。结论 :金银花水提物对卵清蛋白致敏的小鼠Ⅰ型变态反应具有一定治疗作用

Abstract

Objective:To study the effects of the Lonicera on immediate hypersensitiviy

and to provide pharmacological clues for the further clinical practice.Methods:The effects of Lonicera on both the heat-unstable PCA and the heat-stable PCA experiments of the mice were observed

and the changes of the histamine levels in the ovalbumin-induced allergic mouse’s intestines after administrating the Lonicera were detected by observing the histopathologic changes with either HE stain or toludine blue stain and measuring the levels of histamine in the intestines with a fluorescent method.Results:The high and the middle coneatracions of the Lonicera could inhibit the heat-unstable PCA activity in the mice( P <0.01)instead of the heat-stable PCA activity ( P >0.05).The high and middle concentracions of the Lonicera were significantly effective

in increasing the percentage of the intact intestinal mast cells( P <0.01)by mitigating the inflammation of the intestine in HE stain and reducing the releasing of granule and aggregation of the mast cells in the toludine blue stain( <0.01).The high concentracion was significantly different from the middle (P<0.01).Conclusion:The Lonicera might have a potential to treat the ovalbumin-induced immediate hypersensitivity in a murine model.

关键词

金银花食物过敏Ⅰ型变态反应卵清蛋白

Keywords

Lonicerafood allergyImmediate hypersensitivityOvalbumin

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Related Institution

Department of Primary Child Health Care,the Children’s Hospital,Chongqing Medical University,Ministy of Education Key Laboratory of Child department and disorders,China International Science and Technology Cooperation base of Child development and critical disorders,Chongqing Key Laboratory of Pediatrics

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