Instruction on breast-feeding with hepatitis B virus markers positive mothers

WANG Fulan; et al

doi:10.13406/j.cnki.cyxb.2004.02.043

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Instruction on breast-feeding with hepatitis B virus markers positive mothers

更新时间：2024-01-17

- Instruction on breast-feeding with hepatitis B virus markers positive mothers
- Journal of Chongqing Medical University Issue 2, Pages: 251-253(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院妇产科
  2. 重庆医科大学临床学院检验科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.02.043
  CLC： R174
- Published：2004，
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[1]王富兰,张建华,胥飚.指导HBsAg阳性产妇母乳喂养的策略[J].重庆医科大学学报,2004(02):251-253.

WANG Fulan, et al. Instruction on breast-feeding with hepatitis B virus markers positive mothers. [J]. Journal of Chongqing Medical University (2):251-253(2004)
[1]王富兰,张建华,胥飚.指导HBsAg阳性产妇母乳喂养的策略[J].重庆医科大学学报,2004(02):251-253. DOI： 10.13406/j.cnki.cyxb.2004.02.043.

WANG Fulan, et al. Instruction on breast-feeding with hepatitis B virus markers positive mothers. [J]. Journal of Chongqing Medical University (2):251-253(2004) DOI： 10.13406/j.cnki.cyxb.2004.02.043.

摘要

目的 :探讨影响HBsAg阳性产妇母乳喂养的因素及指导母乳喂养的相关实验室和临床依据。方法 :用ELISA法检测孕妇和婴儿（ 12～ 18个月）血清中的乙型肝炎标志物（HBVM）

用荧光定量PCR法检测HBV携带产妇血清和初乳中HBV-DNA含量

并对孕妇和婴儿进行全程免疫防护

然后分析婴儿血清HBVM与母乳喂养和人工喂养的关系。结果 :6 7例HB sAg阳性（大、小三阳）产妇中

HBV血清‘大三阳’的产妇血液、初乳中HBV -DNA阳性率较高

分别为 84 %和 2 6 %。母亲血清HBVM为‘大三阳’者分别占人工喂养组和母乳喂养组的 4 1%和 13%

两组间差异有显著性（P <0 .0 5 ） ;婴儿在 12～ 18个月时作血清HBVM检测

人工喂养组和母乳喂养组婴儿血清抗 -HBs阳性率分别为 84 %和 87%

两组差异无显著性（P >0 .0 5 ）。结论 :HBV携带产妇只要在孕期进行预防干预及对所产婴儿进行被动和主动免疫防范措施

当产妇乳汁中HBV -DNA阴性时进行母乳喂养是相对安全的

Abstract

Objective:To provide a correlation evidence in laboratory for instruction breast-feeding

the investigation of positive rates with serum hepatitis B virus markers(HBVM) in parturients and their infants of breast-feeding to HBVM antigen positive mothers.Methods:The serum HBVM of pregnant women and their infants(12～18th month)were determined by ELISA and HBV-DNA in positive serum and colostrum were determined by fluorescence quantitative PCR

and whole process of immune-protection for pregnant women and their infants.The relation between HBVM in the infant serum and the feeding way was analysed.Results:In 67 case parturient of serum HBVM antigen positive

the positive rate of HBV-DNA was 84%

26% in serum and colostrum with HBeAg positive and HBeAg negative mothers;and there was a positive relationship between the serum and colostrum.The positive rate of HBeAg of serum mothers were 41% and 13% in the artificial feeding group and breast feeding group

there was significant difference between them( P <0.01).After 12～18 months

the infants positive rate of serum anti-HBs was 84% and 87% in the artificial feeding group and breast feeding group( P >0.05).Conclusion:As determinations of HBV-DNA were negative in colostrum

the breast-feeding was safe to HBVM antigen positive mothers by active and passive immunization with pregnant women and their infants.

关键词

乙肝病毒标志物乙肝病毒DNA母乳喂养聚合酶链反应

Keywords

Hepatitis B virus markerHepatitis B virus deoxyribonucleic acid (HBV-DNA)Breast-feedingPolymerase chain reaction (PCR)

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