The alert role of Clara cell secretory protein in serum from patients in the developing course of acute respiratory distress syndrome

LI Minchao; et al

doi:10.13406/j.cnki.cyxb.2004.02.034

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The alert role of Clara cell secretory protein in serum from patients in the developing course of acute respiratory distress syndrome

更新时间：2024-01-17

- The alert role of Clara cell secretory protein in serum from patients in the developing course of acute respiratory distress syndrome
- Journal of Chongqing Medical University Issue 2, Pages: 229-230(2004)
- 作者机构：
  
  1. 重庆医科大学第二临床学院呼吸内科
  2. 重庆医科大学第二临床学院呼吸内科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.02.034
  CLC： R563.8
- Published：2004，
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[1]李敏超,周向东.围急性呼吸窘迫综合征患者血清Clara细胞分泌蛋白水平的预警意义[J].重庆医科大学学报,2004(02):229-230+255.

LI Minchao, et al. The alert role of Clara cell secretory protein in serum from patients in the developing course of acute respiratory distress syndrome. [J]. Journal of Chongqing Medical University (2):229-230(2004)
[1]李敏超,周向东.围急性呼吸窘迫综合征患者血清Clara细胞分泌蛋白水平的预警意义[J].重庆医科大学学报,2004(02):229-230+255. DOI： 10.13406/j.cnki.cyxb.2004.02.034.

LI Minchao, et al. The alert role of Clara cell secretory protein in serum from patients in the developing course of acute respiratory distress syndrome. [J]. Journal of Chongqing Medical University (2):229-230(2004) DOI： 10.13406/j.cnki.cyxb.2004.02.034.

摘要

目的 :为寻找能反映围急性呼吸窘迫综合征（ARDS）患者病情进展的早期预警指标。方法 :采用双抗体夹心酶联免疫吸附（ELISA）法检测正常人及围ARDS患者病程各阶段即系统性炎症反应综合征（SIRS）、急性肺损伤（ALI）、急性呼吸窘迫综合征（ARDS）及临终期血清中肺Clara细胞分泌的特异性蛋白 -CCl6水平。结果 :炎症反应的初期即SIRS时

其血清CC16蛋白水平已比正常显著升高（P <0 .0 1）

随病程恶性进展

CCl6蛋白水平进一步呈进行性升高即ALI期高于SIRS期（P<0 .0 1）

ARDS期高于ALI期（P <0 .0 1）。而临终期与ARDS期比较CC16蛋白水平则无显著差异（P >0 .0 1）。结论 :CCl6是一个反映肺泡上皮及血管内皮细胞完整性的敏感指标。在急性炎症反应的早期即有明显改变

其变化早于血气分析指标的改变

故在临床上可作为早期预警和判断预后的良好指标。

Abstract

Objective:To search for a prophetic marker reflecting the progress of acute respiratory distress syndrome (ARDS).Methods:The serum was obtained from normal controls and patients at difierent stages of ARDS:systemic inflammatory response syndrome (SIRS)

acute lung injury(ALI)

ARDS and just before dying.Clara cell secretory protein (CC16) in serum was detected using enzyme-linked immunoadsordent assay (ELISA).Results:In the early stage of inflammatory reaction

that is

stage of SIRS

the CC16 levels in serum were higher than normal controls ( P <0.01).With the progress of disease

CC16 levels would be gradually higher

that is

CC16 levels of ALI stage were higher than that of SIRS stage ( P <0.01).Similarity was found between SIRS stage and ARDS stage ( P <0.01 ).However CC16 levels at dying stage showed no difference with that of ARDS ( P >0.01).Conclusion:The determination of CC16 in serum is a sensitive marker reflecting the integrity of alveolar epithelium and vascular endothelial cell.The alteration of CC16 is presented in the early period of acute inflammatory reaction.The alteration of CC16 is earlier than that of blood gas analysis.CC16 may serve as a helpful marker to foresee and evaluate prognosis of ARDS in early stage.

关键词

急性呼吸窘迫综合征CCl6系统性炎症反应综合征急性肺损伤

Keywords

acute respiratory distress syndromeClara cell secretory proteinSystemic inflammatory response syndromeacute lung injury

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