The study of the activities of antithrombin Ⅲ in several thrombophilia

YE Yuehong; et al

doi:10.13406/j.cnki.cyxb.2004.02.027

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The study of the activities of antithrombin Ⅲ in several thrombophilia

更新时间：2024-01-17

- The study of the activities of antithrombin Ⅲ in several thrombophilia
- Journal of Chongqing Medical University Issue 2, Pages: 208-210(2004)
- 作者机构：
  
  1. 重庆医科大学第二临床学院检验科
  2. 重庆医科大学第二临床学院检验科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.02.027
  CLC： Q553
- Published：2004，
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[1]叶跃红,李兴禄.抗凝血酶Ⅲ活性在几种易栓症疾病中的研究[J].重庆医科大学学报,2004(02):208-210.

YE Yuehong, et al. The study of the activities of antithrombin Ⅲ in several thrombophilia. [J]. Journal of Chongqing Medical University (2):208-210(2004)
[1]叶跃红,李兴禄.抗凝血酶Ⅲ活性在几种易栓症疾病中的研究[J].重庆医科大学学报,2004(02):208-210. DOI： 10.13406/j.cnki.cyxb.2004.02.027.

YE Yuehong, et al. The study of the activities of antithrombin Ⅲ in several thrombophilia. [J]. Journal of Chongqing Medical University (2):208-210(2004) DOI： 10.13406/j.cnki.cyxb.2004.02.027.

摘要

目的 :测定抗凝血酶Ⅲ活性以期探讨在妊高征、糖尿病、肾病综合征、系统性红斑狼疮和急性非淋巴细胞白血病中的变化及意义。方法 :采用发色底物法分别对妊高征、糖尿病、肾病综合征、系统性红斑狼疮和急性非淋巴细胞白血病及其对照测定抗凝血酶Ⅲ。结果 :（ 1）妊高征者和正常孕妇AT -Ⅲ :A :AT -Ⅲ :A明显低于正常非孕妇女（P <0 .0 1）

并且妊高征者比正常孕妇降低更甚（P <0 .0 0 1）。（ 2 ）糖尿病无并发症组AT -Ⅲ :A与对照组比较

差异无显著性（P >0 .0 5 ）

糖尿病有并发症组与对照组比较

AT -Ⅲ :A显著降低（P <0 .0 1）。（ 3）肾病综合征患者AT -Ⅲ :A明显低于正常对照组（P <0 .0 1）。（ 4 ）系统性红斑狼疮病人AT -Ⅲ :A显著低于对照组（P <0 .0 1）。（ 5 ）急非淋AT -Ⅲ :A明显低于正常对照组（P <0 .0 5 ）。结论 :检测AT -Ⅲ :A在易栓症的诊断中具有重要意义

Abstract

Objective:To investigate thc changes and clinical significance of antithrombin Ⅲin pregnancy induced hyperternsion(PIH)

diabetes mellitus(DM)

nephritic syndrome(NS)

systemic lupus erythematosus(SLE) and acute non-lymphoid cell leukemia(ANLL).Methods:AT-Ⅲ:A was measured by chromogonic substratc method in pregnancy induced hypertension(PIH)

diabetes mellitus(DM)

nephritic syndrome(NS)

systemic lupus erythematosus(SLE)

acute non-lymphoid cell leukemia(ANLL) and control group.Results:AT-Ⅲ:A in women with PIH and normal prcgnancy and the DM with conplication and the NS and the SLE and the ANLL was significantly lower than that in the control.No significant difference in AT-Ⅲ:A was found between the DM without complication and the control.Conclusion:Determination of AT-Ⅲ:A has great value in the diagnosis of thrombophilia.

关键词

抗凝血酶Ⅲ妊高征糖尿病肾病综合征系统性红斑狼疮:急性非淋巴细胞白血病

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