A randomized comparative study on the effect of gatifloxacin and ciprofloxacin therapy in urinary tract and genital bacterial infections

YAO Yunqing; et al

doi:10.13406/j.cnki.cyxb.2004.02.021

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A randomized comparative study on the effect of gatifloxacin and ciprofloxacin therapy in urinary tract and genital bacterial infections

更新时间：2024-01-17

- A randomized comparative study on the effect of gatifloxacin and ciprofloxacin therapy in urinary tract and genital bacterial infections
- Journal of Chongqing Medical University Issue 2, Pages: 191-193(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院感染科
  2. 重庆医科大学临床学院感染科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.02.021
  CLC： R691.3
- Published：2004，
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[1]姚云清,卢萍,肖永红,段明纲,邹启园,余泽波,曾爱中,刘鸿渝,李崇智.国产甲磺酸加替沙星片治疗泌尿生殖系统细菌性感染疗效观察[J].重庆医科大学学报,2004(02):191-193+224.

YAO Yunqing, et al. A randomized comparative study on the effect of gatifloxacin and ciprofloxacin therapy in urinary tract and genital bacterial infections. [J]. Journal of Chongqing Medical University (2):191-193(2004)
[1]姚云清,卢萍,肖永红,段明纲,邹启园,余泽波,曾爱中,刘鸿渝,李崇智.国产甲磺酸加替沙星片治疗泌尿生殖系统细菌性感染疗效观察[J].重庆医科大学学报,2004(02):191-193+224. DOI： 10.13406/j.cnki.cyxb.2004.02.021.

YAO Yunqing, et al. A randomized comparative study on the effect of gatifloxacin and ciprofloxacin therapy in urinary tract and genital bacterial infections. [J]. Journal of Chongqing Medical University (2):191-193(2004) DOI： 10.13406/j.cnki.cyxb.2004.02.021.

摘要

目的 :以甲磺酸加替沙星片和盐酸环丙沙星片随机对照治疗轻、中度急性泌尿道 /生殖道细菌感染

评价国产甲磺酸加替沙星片的疗效及安全性。方法 :试验组 2 4例患者接受甲磺酸加替沙星片 2 0 0mg口服

每日 2次 ;对照组 2 0例接受盐酸环丙沙星片 2 5 0mg

每日 3次

疗程 7～ 14天。结果 :试验组和对照组痊愈率和有效率分别为 87.5 %、70 .0 % （P >0 .0 5 ）与10 0 .0 %、90 .0 % （P >0 .0 5 ）。两组的细菌阳性率、清除率分别为 87.5 %、80 .0 % （P >0 .0 5 ）和 10 0 .0 %、87.5 % （P >0 .0 5 ）。甲磺酸加替沙星的抗菌活性与环丙沙星、司氟沙星比较差异有显著性（P <0 .0 5 ）

但与左氧氟沙星、头孢噻肟及青霉素相比差异无显著性（P >0 .0 5 ）。两组不良反应发生率分别为 8.3%和 5 .0 % （P >0 .0 5 ）。结论 :国产甲磺酸加替沙星片治疗轻、中度急性泌尿道 /生殖道细菌感染安全、高效

Abstract

Objective:To evaluate the clinical efficacy and safety of gatifloxacin in the treatment of urinary tract and genital bacterial infections.Methods:24 patients in study group were treated with 200 mg of gatifloxacin orally ql2hr

and 20 patients in control group were administered with 250 mg of ciprofloxacin orally q8hr for 7 days to 14 days.Results:The cure rate and the effective rate of the two groups were 87.5%

70.0% ( P >0.05) and 100.0%

90.0% ( P >0.05)

respectively.The bacterial positive and eradication rates of the two groups were 87.5%?80.0% ( P >0.05) and 100.0%?87.5% ( P >0.05)

respectively.Sensitivity rate of 37 bacterial strains to gatifloxacin

ciprofloxacin

levofloxacin

sipafloxacin

cefataxime and penicillin(for gonococcus) were 100.0%

86.5%

94.6%

76.5%

91.9%

100.0%

respectively.Adverse events were generally mild

and adverse events rates of the two groups were 8.3% and 5.0%

respectively.Conclusion:Gatifloxacin is an highly effective and well tolerated antibacterial agent for the treatment of urinary tract and genital bacterial infections.

关键词

甲磺酸加替沙星环丙沙星临床疗效细菌学疗效细菌性感染

Keywords

GatifloxacinCiprofloxacinclinical efficacyBacteriological effectBacterial infections

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