A light and an electron microscopy study on inhibition of Eleo-Zedoary to human endometrial cancer

ZHAO Hua; et al

doi:10.13406/j.cnki.cyxb.2004.02.017

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A light and an electron microscopy study on inhibition of Eleo-Zedoary to human endometrial cancer

更新时间：2024-01-17

- A light and an electron microscopy study on inhibition of Eleo-Zedoary to human endometrial cancer
- Journal of Chongqing Medical University Issue 2, Pages: 176-180(2004)
- 作者机构：
  
  1. 重庆医科大学基础医学院病理生理教研室
  2. 重庆医科大学基础医学院病理生理教研室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.02.017
  CLC： R737.33
- Published：2004，
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[1]赵华,骆云鹏.莪术对人子宫内膜癌作用的光镜及超微结构研究[J].重庆医科大学学报,2004(02):176-180.

ZHAO Hua, et al. A light and an electron microscopy study on inhibition of Eleo-Zedoary to human endometrial cancer. [J]. Journal of Chongqing Medical University (2):176-180(2004)
[1]赵华,骆云鹏.莪术对人子宫内膜癌作用的光镜及超微结构研究[J].重庆医科大学学报,2004(02):176-180. DOI： 10.13406/j.cnki.cyxb.2004.02.017.

ZHAO Hua, et al. A light and an electron microscopy study on inhibition of Eleo-Zedoary to human endometrial cancer. [J]. Journal of Chongqing Medical University (2):176-180(2004) DOI： 10.13406/j.cnki.cyxb.2004.02.017.

摘要

目的 :研究莪术油注射液在体外对人子宫内膜癌细胞株RL - 95 2生长的抑制作用及其可能机制。方法 :通过MTT法实验观察莪术油注射液在体外对RL - 95 2的抑制作用 ;光镜及透射电镜观察癌细胞的形态学改变。结果 :莪术油注射液对RL - 95 2的抑制率呈时间 -剂量依赖性。光镜下见 :癌细胞核固缩

胞浆有大量的空泡出现 ;透射电镜见 :细胞浆内细胞器明显肿胀

线粒体嵴增粗 ;细胞染色质断裂、凝集。结论 :莪术油注射液在体外作用于人子宫内膜癌细胞株RL - 95 2

可能系通过非凋亡性程序性死亡方式抑制癌细胞增殖

Abstract

Objective:To investigate the inhibition of Eleo-Zedoary solution to human endometrial cancer cell line RL-952 in vitro and its possible mechanism.Methods:Using the MTT assay to display the sensitivity to the drug

the inhibition of Eleo-Zedoary parenteral solution to RL-952 cells in vitro was observed;and using light microscope and transmission electron microscope

the morphological alterations of the cells were observed.Results:The inhibition rate of Eleo-Zedoary parenteral solution to RL-952 indicated both dose-dependent and time-dependent anti-proliferative effect.Microscopically

the large vacuoles in the cytoplasm of the cells were found.Ultramicroscopically

many fat-like drops and obvious swelling of organelles as well as the mitochondrial cristaes in the cytoplasm of cells were observed.In addition the nucleus concentration and the chromatin fragmentation and coagulation

including the apoptotic bodies were observed.Conclusion:Eleo-Zedoary parenteral solution can inhibit the proliferation of human endometrial cancer cell line RL-952 by induing apoptosis and secondary necrosis.

关键词

莪术人子宫内膜癌细胞株RL-952坏死细胞凋亡

Keywords

Eleo-Zedoary parenteral solutionHuman endometrial cancer cell line RL-952ApoptosisNecrosis

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