Analysis about the relationship between thyroid hormone and leptin in Graves’ disease of woman

LIU Dongfang; et al

doi:10.13406/j.cnki.cyxb.2004.02.014

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Analysis about the relationship between thyroid hormone and leptin in Graves’ disease of woman

更新时间：2024-01-17

- Analysis about the relationship between thyroid hormone and leptin in Graves’ disease of woman
- Journal of Chongqing Medical University Issue 2, Pages: 166-168(2004)
- 作者机构：
  
  1. 重庆医科大学第二临床学院内分泌科
  2. 重庆长安厂医院内科
  3. 重庆医科大学第二临床学院内分泌科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.02.014
  CLC： R581.1
- Published：2004，
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[1]刘东方,程伟,吴玲,庞久高.女性Grave’s病患者甲状腺激素与瘦素关系探讨[J].重庆医科大学学报,2004(02):166-168.

LIU Dongfang, et al. Analysis about the relationship between thyroid hormone and leptin in Graves’ disease of woman. [J]. Journal of Chongqing Medical University (2):166-168(2004)
[1]刘东方,程伟,吴玲,庞久高.女性Grave’s病患者甲状腺激素与瘦素关系探讨[J].重庆医科大学学报,2004(02):166-168. DOI： 10.13406/j.cnki.cyxb.2004.02.014.

LIU Dongfang, et al. Analysis about the relationship between thyroid hormone and leptin in Graves’ disease of woman. [J]. Journal of Chongqing Medical University (2):166-168(2004) DOI： 10.13406/j.cnki.cyxb.2004.02.014.

摘要

目的 :探讨Grave’s病患者瘦素水平变化

进一步明确甲状腺机能亢进状态下甲状腺激素对瘦素分泌的影响。方法 :测定 30例新诊断女性Grave’s病患者和 30例正常女性对照的FT3、FT4、TSH、体重、血瘦素水平

算出体脂含量（FAT % ）和 %瘦素

观察用他巴唑治疗 6月后各指标的变化

分析甲状腺激素与瘦素和 %瘦素的关系

并将各因素与瘦素和 %瘦素行多元回归分析。结果 :Grave’s病患者BMI、FAT %和瘦素水平低于正常女性

但 %瘦素高于正常女性

治疗 6月后瘦素水平似有提高但并无显著意义

而 %瘦素却较治疗前明显下降

相关分析表明FT3、FT4、BMI、FAT %与 %瘦素显著相关。结论 :女性甲亢患者 %瘦素高于正常女性

甲亢状态下甲状腺激素在瘦素分泌中依然起上调作用

Abstract

Objective:To investigate the relationship of hyperthyroidism and the level of leptin and the role of thyroid hormone in leptin secretion.Methods:FT3

FT4

TSH

serum leptin and body weight were measured in 30 female Graves’ patients and 30 female controls;the percentage of body fat and leptin were calculated

the changes in various index after 6-month treatment with methimazole were observed

the relationship between thyroid hormone and leptin

percentage of leptin analyzed

and multiple regressive analysis was made on these factors.Results:The BMI

percentage of body fat and leptin level were lower than controls

however

percentage of leptin was higher than controls.The leptin level elevated insignificantly but percentage of leptin decreased significantly after 6 months treatment with methimazole.Percentage of leptin showed positive correlation with FT3

FT4 and BMI percentage of body fat.Conclusion:The percentage of leptin is higher in female thyroid hyperfunction patients than controls and thyroid hormone increases the secretion of leptin even on the condition of thyroid hyperfunction.

关键词

甲状腺机能亢进症甲状腺激素瘦素

Keywords

Hyperthyroidismthyroid hormoneleptin

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