Effect of mild hypothermia on severe head injuries through monitoring brain tissue PO<sub>2</sub>

HE Jianguo; et al

doi:10.13406/j.cnki.cyxb.2004.02.012

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Effect of mild hypothermia on severe head injuries through monitoring brain tissue PO₂

更新时间：2024-01-17

- Effect of mild hypothermia on severe head injuries through monitoring brain tissue PO₂
- Journal of Chongqing Medical University Issue 2, Pages: 159-161(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院神经外科
  2. 重庆医科大学临床学院神经外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.02.012
  CLC： R651
- Published：2004，
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[1]何建国,唐文渊.从脑氧代谢角度探讨亚低温治疗重型颅脑损伤的近期疗效[J].重庆医科大学学报,2004(02):159-161+175.

HE Jianguo, et al. Effect of mild hypothermia on severe head injuries through monitoring brain tissue PO₂. [J]. Journal of Chongqing Medical University (2):159-161(2004)
[1]何建国,唐文渊.从脑氧代谢角度探讨亚低温治疗重型颅脑损伤的近期疗效[J].重庆医科大学学报,2004(02):159-161+175. DOI： 10.13406/j.cnki.cyxb.2004.02.012.

HE Jianguo, et al. Effect of mild hypothermia on severe head injuries through monitoring brain tissue PO₂. [J]. Journal of Chongqing Medical University (2):159-161(2004) DOI： 10.13406/j.cnki.cyxb.2004.02.012.

摘要

目的 :对重型颅脑损伤患者在亚低温治疗过程中的脑组织氧分压（Braintissueoxygenpressure -PbrO2 ）变化进行监测、分析

探讨亚低温治疗重型颅脑损伤的近期疗效。方法 :重型脑外伤患者 4 2例

分为亚低温组、对照组。亚低温组于伤后 12h内行亚低温治疗（ 32～ 34℃ ）

时程 3～ 5天 ;对照组予以常规治疗。两组均持续监测PbrO2

并对不同时段PbrO2 行统计学分析。结果 :亚低温组和对照组重型颅脑损伤（GCS6～ 8分）患者于降温前、降温 4h时段及复温后的PbrO2 无显著差异（P >0 .0 5 ）

但亚低温组在降温 2 4、4 8、72h时段PbrO2 均低于对照组（P <0 .0 5 ）。亚低温组与对照组特重型颅脑损伤（GCS3～ 5分）患者各时段PbrO2 无显著差异（P >0 .0 5 ）。亚低温组中重型颅脑损伤患者的死亡率低于对照组（P <0 .0 5 ）

而特重型颅脑损伤患者的死亡率与对照组相比无显著差异（P >0 .0 5 ）。结论 :亚低温治疗重型颅脑损伤（GCS6～ 8分）能降低患者的死亡率

同时也降低了PbrO2 ;对特重型颅脑损伤（GCS3～ 5分）无明显治疗作用。

Abstract

Objective:To further study the clime value of mild hypothermia for severe head injury through monitoring and analyzing the changes of brain tissue PO 2 (P br O 2) in patients with severe head injury.Methods:42 patients with severe head injury were selected for this study.Mild hypothermia group received cooling 32～34℃

for 3～5 days within 12 hours after head injury.Control group received ordinary treatment.P br O 2 in all patients were continuously monitored.Results:There was no difference in P br O 2 between severe head injury patients in both groups (GCS 6～8) before cooling

4 hours after cooling or after rewarming( P >0.05 );P br O 2 was lower in cooling group than that in control group at 24 hours/48 hours/72 hours after cooling ( P <0.05 ).There was no difference between patients with GCS 3～5 in both groups at different periods ( P >0.05).The mortality rate of patients with severe head injury (GCS 6～8) in mild hypothermia group is obviously lower than that in control group ( P <0.05).There was no difference in mortality rate between patients with GCS 3～5 in two groups.Conclusion:The mortality rate of severe head injury (GCS 6～8) patients decreased through mild hypothermia therapy

but P br O 2 of the severe head injury (GCS 6～8) patients treated with mild hypothermia decreased at the same time.To patients with GCS 3～5

mild hypothermia therapy is ineffective.

关键词

脑损伤亚低温脑氧分压死亡率

Keywords

brain injuryMild hypothermiaP br O2mortality rate

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Effect of mild hypothermia on severe head injuries through monitoring brain tissue PO2

DOI：10.13406/j.cnki.cyxb.2004.02.012

摘要

Abstract

关键词

Keywords

references

Effect of mild hypothermia on severe head injuries through monitoring brain tissue PO₂