Objective:To evaluate the effects of ciprofloxacin on the heart and brain electrical power spectra of rats.Methods:Male wistar rats received ciprofloxacin 100mg/kg through their jugular vein.The heart and brain electrical power spectra of rats were recorded before administration as contrast

and at 10

20

30

60

120 minutes after administration as experiments respectively.RR 512 soft ware was used to analyze heart electrical RR variance and low frequency power and high frequency power

and Coherence software was employed to study brain electrical δ

θ

α

β power.Results:At 10 - 6 0minafter do sage

heartelectrical RRvariance was distinct lylarger

and low frequencypower was evidentlylower

and highfrequencypower was signi ficantly higher than those determined be foreadministration .SpikewavesfrequentlyappearedintheECOGofratsat 13minto 6 0minafteradministration .At 10minafter dosage

thebrainelectricaltotalpowerandδpowerweredistinctlylowerthanthosebeforeadministration .At 12 0min

θ

α

βwave powerwereobviouslyhigher

andδ/θandδ/(θ +α +β)valuewereevidentlylowerthanthosebeforeadministration

buttheywere notchangedatothertimes.Conclusion :The excitability of sympathe ticnerv eof the heartwas weakened and the irritability of pneu mogastricnerve was enhanced

and the hear tratevariabi lity in creases

and the excitability of centralnerve was induced by cipr of loxacin .