The effect of Astragalus membranaceus on serum NO in patients with  chronic glomerulonephritis at pre-renal failure phase

CHEN Xuemei; et al

doi:10.13406/j.cnki.cyxb.2004.01.024

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The effect of Astragalus membranaceus on serum NO in patients with chronic glomerulonephritis at pre-renal failure phase

更新时间：2024-01-17

- The effect of Astragalus membranaceus on serum NO in patients with chronic glomerulonephritis at pre-renal failure phase
- Journal of Chongqing Medical University Issue 1, Pages: 77-79(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院急诊科
  2. 重庆医科大学临床学院中医科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.01.024
  CLC： R277.51
- Published：2004，
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[1]陈雪梅,李荣亨.黄芪对慢性肾炎非肾衰竭期患者血清NO的影响[J].重庆医科大学学报,2004(01):77-79.

CHEN Xuemei, et al. The effect of Astragalus membranaceus on serum NO in patients with chronic glomerulonephritis at pre-renal failure phase. [J]. Journal of Chongqing Medical University (1):77-79(2004)
[1]陈雪梅,李荣亨.黄芪对慢性肾炎非肾衰竭期患者血清NO的影响[J].重庆医科大学学报,2004(01):77-79. DOI： 10.13406/j.cnki.cyxb.2004.01.024.

CHEN Xuemei, et al. The effect of Astragalus membranaceus on serum NO in patients with chronic glomerulonephritis at pre-renal failure phase. [J]. Journal of Chongqing Medical University (1):77-79(2004) DOI： 10.13406/j.cnki.cyxb.2004.01.024.

摘要

目的 :探讨黄芪对慢性肾炎非肾衰竭期患者血清NO的影响。方法 :应用化学比色法

测定 31例正常人及 92例慢性肾炎非肾衰竭期患者的血清NO水平

并观察黄芪治疗前后NO的变化。结果 :1.患者组血清NO水平较对照组明显降低 ;且随肾功能损害加重

血清NO水平有逐渐下降趋势。 2 .与常规治疗组比较

黄芪治疗后

患者血清NO水平显著升高

尿蛋白显著降低

但肾功能无显著变化。结论 :慢性肾炎非肾衰竭期患者体内NO合成及释放不足

黄芪可促进NO合成增加

减少尿蛋白。

Abstract

Objective:To observe the effect of Astragalus membranaceus on serum NO in patients with chronic glomerulonephritis at pre-renal failure phase.Methods:The levels of serum NO 3 -/NO 2 - that can indirectly reflect serum nitric oxide were measured in 92 cases of chronic glomerulonephritis (CGN) at pre-renal failure phase and 31 normal subjects by chemical colorimetry.Renal function

serum NO and urinary protein of patients were examined before and after treatment with or without Astragalus membranaceus.Results:1.The levels of serum NO 3 -/NO 2 - in patients were significantly lower than those in the control group

with the lesions of renal function aggravating

the levels of serum NO 3 -/NO 2 - decreasing gradually.2.Astragalus membranaceus could remarkably increase serum NO 3 -/NO 2 - and decrease urinary protein.Conclusion:In patients with chronic glomerulonephritis at pre-renal failure phase

NO is insufficiednt.Astragalus membranaceus may contribute to the synthesis of NO and the decrease in urinary protein excretion.

关键词

慢性肾小球肾炎一氧化氮黄芪

Keywords

Chronic glomerulonephritsnitric oxideastragalus membranaceus

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