Comparision of the efficacy between carvedilol and atenolol   in treating chronic congestive heart failure

HU Yongmei; et al

doi:10.13406/j.cnki.cyxb.2004.01.023

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Comparision of the efficacy between carvedilol and atenolol in treating chronic congestive heart failure

更新时间：2024-01-17

- Comparision of the efficacy between carvedilol and atenolol in treating chronic congestive heart failure
- Journal of Chongqing Medical University Issue 1, Pages: 74-76(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院心内科
  2. 重庆医科大学临床学院心内科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.01.023
  CLC： R541.6
- Published：2004，
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[1]胡咏梅,李法琦,余江恒,罗羽慧.卡维地洛和阿替洛尔治疗心衰疗效的观察[J].重庆医科大学学报,2004(01):74-76.

HU Yongmei, et al. Comparision of the efficacy between carvedilol and atenolol in treating chronic congestive heart failure. [J]. Journal of Chongqing Medical University (1):74-76(2004)
[1]胡咏梅,李法琦,余江恒,罗羽慧.卡维地洛和阿替洛尔治疗心衰疗效的观察[J].重庆医科大学学报,2004(01):74-76. DOI： 10.13406/j.cnki.cyxb.2004.01.023.

HU Yongmei, et al. Comparision of the efficacy between carvedilol and atenolol in treating chronic congestive heart failure. [J]. Journal of Chongqing Medical University (1):74-76(2004) DOI： 10.13406/j.cnki.cyxb.2004.01.023.

摘要

目的 :比较卡维地洛和阿替洛尔对心衰的疗效。方法 :构建后负荷增高型心衰模型

卡维地洛和阿替洛尔干预 4周

观察心功能指标、心室重构情况。结果 :心衰组心功能恶化

卡维地洛和阿替洛尔降低心率（HR）及平均动脉压（MBP）

改善心衰大鼠左室舒张末压（LVEDP）和 -dp/dtmax（P <0 .0 1～ 0 .0 5 ） ;卡维地洛提高左室收缩压（LVSP）和 +dp/dtmax（P <0 .0 1～ 0 .0 5 ） ;心衰组左室质量指数（LVMI）和右室质量指数（RVMI）增加（P均 <0 .0 5 ）

卡维地洛明显降低LVMI及RVMI（P均 <0 .0 5 ）

与阿替洛尔有显著性差异（P均 <0 .0 1）。结论 :阿替洛尔和卡维地洛均能改善心功能

前者改善心脏舒张功能

后者对收缩、舒张功能均有疗效。卡维地洛能抑制心室重构

有利于心衰的远期预后。

Abstract

Objective:To compare the effects between carvedilol and atenolol in treating congestive heart failure of rat models

and to discuss the mechanism of carvedilol.Methods:8 weeks after partial ligating abdominal aorta

30 rats were randomly divided into 3 groups:heart failure group(n=10)

carvedilol group(n=10) and atenolol group(n=10).Sham-operated group(n=10) were selected randomly as control.After 4 weeks of medical therapy

hemodynamic parameters and ventricular mass index were studied.Results:Compared with sham-operated group

all the hemodynamic parameters in heart failure group were deteriorated.In carvedilol and atenolol groups

heart rate(HR) and mean blood pressure(MBP) were decreased(P<0.01～0.05)

and left ventricular end -diastolic pressure(LVEDP) and -dp/dt max improved significantly(P<0.05).Besides

left ventricular systolic pressure(LVSP) and +dp/dt max in carvedilol group were increased greatly(P<0.01～0.05)。In comparison with sham-operated group

left ventricular mass index(LVMI) and right ventricular mass index(RVMI) in heart failure group were increased by 19% and 30% respectively(P<0.01～0.05).Carvedilol decreased LVMI and RVMI

compared with heart failure group and atenolol group(P<0.01～0.05).Conclusion:Both carvedilol and atenolol can improve failing heart function.While atenolol mainly improves diastolic function

carvedilol has effect both on systolic and diastolic function

and it can protect against ventricular remodeling

which is of benefit for prognosis of heart failure.

关键词

卡维地洛阿替洛尔心力衰竭大鼠

Keywords

CarvedilolAtenololheart failurerat

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