Expression of TGF-β1 protein and its significance in colorectal carcinoma tissues

TANG Hua et; al

doi:10.13406/j.cnki.cyxb.2004.01.022

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Expression of TGF-β1 protein and its significance in colorectal carcinoma tissues

更新时间：2024-01-17

- Expression of TGF-β1 protein and its significance in colorectal carcinoma tissues
- Journal of Chongqing Medical University Issue 1, Pages: 71-73(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院普外科
  2. 重庆医科大学临床学院普外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.01.022
  CLC： R735.3
- Published：2004，
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[1]唐华,张才全.TGF-β1蛋白在大肠癌组织的表达及意义[J].重庆医科大学学报,2004(01):71-73.

TANG Hua et, al. Expression of TGF-β1 protein and its significance in colorectal carcinoma tissues. [J]. Journal of Chongqing Medical University (1):71-73(2004)
[1]唐华,张才全.TGF-β1蛋白在大肠癌组织的表达及意义[J].重庆医科大学学报,2004(01):71-73. DOI： 10.13406/j.cnki.cyxb.2004.01.022.

TANG Hua et, al. Expression of TGF-β1 protein and its significance in colorectal carcinoma tissues. [J]. Journal of Chongqing Medical University (1):71-73(2004) DOI： 10.13406/j.cnki.cyxb.2004.01.022.

摘要

目的 :研究转化生长因子 β1（TGF - β1）在大肠癌组织的表达及临床意义。方法 :运用免疫组化S -P法检测 70例大肠癌组织、10例正常大肠粘膜组织标本的TGF - β1表达

并分析TGF - β1表达与大肠癌临床病理因素及术后生存率的关系。结果 :大肠癌组织TGF - β1表达较正常大肠粘膜明显增强 ;TGF - β1过度表达与大肠癌淋巴结转移、Dukes分期及预后密切相关。结论 :TGF - β1促进大肠癌细胞浸润和转移并影响预后 ;TGF - β1表达可作为大肠癌预测复发和判断预后具有参考意义的新指标。

Abstract

Objective:To investigate the expression of TGF-β1 and its clinical significance in colorectal carcinoma(CRC).Methods:The expression of TGF-β1 in seventy patients with CRC and 10 normal colorectal mucosal tissues were examined by immunohistochemistry

and the expression of TGF-β1 was analyzed with relation to clinicopathologic factors and post-operative survival.Results:Compared with the normal colorectal mucosal tissues

the expression of TGF-β1 in CRC was higher.The overexpression of TGF-β1 is associated with lymph node metastasis

Dukes staging and poor prognosis in patients with CRC.Conclusion:TGF-β1 stimulates CRC cells infiltration and metastasis.The expression of TGF-β1 appears to be a new prognostic factor for the prediction of outcome in patients with CRC.

关键词

大肠肿瘤转化生长因子β1

Keywords

Colorectal neoplasmstransforming growth factor β1

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